R P Shank
Overview
Explore the profile of R P Shank including associated specialties, affiliations and a list of published articles.
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82
Citations
1896
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Recent Articles
1.
Zhao B, Shank R, Plata-Salaman C
Neuroreport
. 2001 Apr;
12(5):1031-4.
PMID: 11303740
Topiramate is a structurally novel neurotherapeutic agent with a unique combination of pharmacological properties and currently is available in most world markets for treating several seizure disorders. Because its pharmacological...
2.
Wang H, Lee D, Davis C, Shank R
J Neurochem
. 2000 Aug;
75(3):1155-61.
PMID: 10936198
We have recently reported evidence that a very high affinity interaction between the beta-amyloid peptide Abeta(1-42) and the alpha7 nicotinic acetylcholine receptor (alpha7nAChR) may be a precipitating event in the...
3.
Scott M, Ross T, Lee D, Wang H, Shank R, Wild K, et al.
Bioorg Med Chem
. 2000 Jul;
8(6):1383-91.
PMID: 10896115
The neuropeptide galanin modulates several physiological functions such as cognition, learning, feeding behavior, and depression, probably via the galanin 1 receptor (GAL-R1). Using an HTS assay based on 125I-human galanin...
4.
Lee J, Davis C, Rivero R, Reitz A, Shank R
Bioorg Med Chem Lett
. 2000 Jun;
10(10):1063-6.
PMID: 10843217
The preparation of novel pyridyl ethers as ligands for the nicotinic acetylcholine receptor (nAChR) is described. Variations of the ring size of the azacycle and substitution on the pyridine had...
5.
Scott M, Demeter D, Nortey S, DUBINSKY B, Shank R, Reitz A
Prog Med Chem
. 2000 May;
36:169-200.
PMID: 10818673
Agents to treat anxiety have gained in acceptance and importance in the fast pace of life in the second half of this century. The discovery and refinement of the benzodiazepines...
6.
Smith L, Hughes K, Egebjerg J, Poulsen F, Wiberg F, Shank R
Epilepsia
. 2000 Apr;
41(S1):48-51.
PMID: 10768301
Purpose: This study was undertaken to test the hypothesis that topiramate (TPM) exerts a negative modulatory effect on some types of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA)/kainate receptors by binding to the site...
7.
Dodgson S, Shank R, Maryanoff B
Epilepsia
. 2000 Apr;
41(S1):35-9.
PMID: 10768298
Purpose: This study investigated the effectiveness of topiramate (TPM) as an inhibitor of six isozymes of carbonic anhydrase (CA). Methods: The inhibition constants (Ki) of TPM and acetazolamide (AZM) for...
8.
Shank R, GARDOCKI J, Streeter A, Maryanoff B
Epilepsia
. 2000 Apr;
41(S1):3-9.
PMID: 10768292
In this overview, we discuss the discovery and development of topiramate (TPM) as an anticonvulsant, including notable aspects of its chemical, biologic, and pharmacokinetic properties. In particular, we highlight its...
9.
Wang H, Lee D, Dandrea M, Peterson P, Shank R, Reitz A
J Biol Chem
. 2000 Feb;
275(8):5626-32.
PMID: 10681545
Alzheimer's disease pathology is characterized by the presence of neuritic plaques and the loss of cholinergic neurons in the brain. The underlying mechanisms leading to these events are unclear, but...
10.
Wang H, Wild K, Shank R, Lee D
Neuropeptides
. 2000 Feb;
33(3):197-205.
PMID: 10657492
Galanin has been implicated in various physiological functions including memory, feeding and pain perception. Using rat cerebral cortical slices and synaptosome preparations incubated with [(3)H]choline in Kreb's-Ringer solution, galanin was...