R P Remmel
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Explore the profile of R P Remmel including associated specialties, affiliations and a list of published articles.
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75
Citations
865
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Recent Articles
1.
Oetting W, Wu B, Schladt D, Guan W, Remmel R, Mannon R, et al.
Pharmacogenomics J
. 2017 Nov;
18(3):501-505.
PMID: 29160300
The immunosuppressant tacrolimus (TAC) is metabolized by both cytochrome P450 3A4 (CYP3A4) and CYP3A5 enzymes. It is common for European Americans (EA) to carry two CYP3A5 loss-of-function (LoF) variants that...
2.
Sanghavi K, Brundage R, Miller M, Schladt D, Israni A, Guan W, et al.
Pharmacogenomics J
. 2015 Dec;
17(1):61-68.
PMID: 26667830
Tacrolimus is dependent on CYP3A5 enzyme for metabolism. Expression of the CYP3A5 enzyme is controlled by several alleles including CYP3A5*1, CYP3A5*3, CYP3A5*6 and CYP3A5*7. African Americans (AAs) have on average...
3.
Oetting W, Schladt D, Guan W, Miller M, Remmel R, Dorr C, et al.
Am J Transplant
. 2015 Oct;
16(2):574-82.
PMID: 26485092
We previously reported that tacrolimus (TAC) trough blood concentrations for African American (AA) kidney allograft recipients were lower than those observed in white patients. Subtherapeutic TAC troughs may be associated...
4.
Hu W, Friend J, Wu F, Sielaff T, Peshwa M, Lazar A, et al.
Cytotechnology
. 2012 Feb;
23(1-3):29-38.
PMID: 22358518
Liver failure is a major cause of mortality. A bioartificial liver (BAL) employing isolated hepatocytes can potentially provide temporary support for liver failure patients. We have developed a bioartificial liver...
5.
Friend J, Wu F, Hansen L, Remmel R, Hu W
Methods Mol Med
. 2011 Mar;
18:245-52.
PMID: 21370181
Several investigators have demonstrated that freshly harvested hepatocytes self-assemble into three-dimensional, compacted, freely suspended aggregates known as spheroids (1-3). These aggregates have smooth, undulating surfaces and average approx 120 µm...
6.
Argikar U, Senekeo-Effenberger K, LARSON E, Tukey R, Remmel R
Xenobiotica
. 2009 Oct;
39(11):826-35.
PMID: 19845433
A transgenic 'knock-in' mouse model expressing a human UGT1 locus (Tg-UGT1) was recently developed and validated. Although these animals express mouse UGT1A proteins, UGT1A4 is a pseudo-gene in mice. Therefore,...
7.
Argikar U, Remmel R
Xenobiotica
. 2009 Apr;
39(5):355-63.
PMID: 19387891
Lamotrigine (LTG), a diaminotriazine anti-epileptic, is principally metabolized at the 2-position of the triazine ring to form a quaternary ammonium glucuronide (LTGG) by uridine glucuronosyl transferease (UGT) 1A3 and UGT1A4....
8.
Kumar A, Mann H, Remmel R
J Vet Pharmacol Ther
. 2006 Nov;
29(6):587-9.
PMID: 17083465
No abstract available.
9.
Nagar S, Remmel R
Oncogene
. 2006 Mar;
25(11):1659-72.
PMID: 16550166
The uridine diphosphoglucuronosyltransferases (UGTs) belong to a superfamily of enzymes that catalyse the glucuronidation of numerous endobiotics and xenobiotics. Several human hepatic and extrahepatic UGT isozymes have been characterized with...
10.
Jacobson P, Green K, Birnbaum A, Remmel R
Cancer Chemother Pharmacol
. 2002 Jul;
49(6):461-7.
PMID: 12107550
Purpose: To establish the cytochrome P450 (CYP) isozymes involved in the metabolism of the alkylating agent, thiotepa, to the pharmacologically active metabolite, TEPA. Methods: In vitro chemical inhibition studies were...