R C Brundage
Overview
Explore the profile of R C Brundage including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
555
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Recent Articles
1.
Sanghavi K, Brundage R, Miller M, Schladt D, Israni A, Guan W, et al.
Pharmacogenomics J
. 2015 Dec;
17(1):61-68.
PMID: 26667830
Tacrolimus is dependent on CYP3A5 enzyme for metabolism. Expression of the CYP3A5 enzyme is controlled by several alleles including CYP3A5*1, CYP3A5*3, CYP3A5*6 and CYP3A5*7. African Americans (AAs) have on average...
2.
Khatri A, Williams B, Fisher J, Brundage R, Gurvich V, Lis L, et al.
Br J Cancer
. 2013 Dec;
110(2):304-12.
PMID: 24300978
Background: Gemcitabine is used for the treatment of several solid tumours and exhibits high inter-individual pharmacokinetic variability. In this study, we explore possible predictive covariates on drug and metabolite disposition....
3.
Milan Segovia R, Dominguez Ramirez A, Jung Cook H, Magana Aquino M, Vigna Perez M, Brundage R, et al.
J Clin Pharm Ther
. 2012 Nov;
38(1):56-61.
PMID: 23167603
What Is Known And Objective: Rifampicin (RIF) shows wide variability in its pharmacokinetics. The purpose of this study was to develop and validate a population pharmacokinetic model to characterize the...
4.
Marino S, Birnbaum A, Leppik I, Conway J, Musib L, Brundage R, et al.
Clin Pharmacol Ther
. 2012 Jan;
91(3):483-8.
PMID: 22278332
Carbamazepine is a widely prescribed antiepileptic drug. Owing to the lack of an intravenous formulation, its absolute bioavailability, absolute clearance, and half-life in patients at steady state have not been...
5.
Castro N, Marquez-Caraveo C, Brundage R, Gonzalez-Esquivel D, Suarez A, Gongora F, et al.
Int J Clin Pharmacol Ther
. 2009 Oct;
47(11):679-85.
PMID: 19840532
Objectives: To determine a population pharmacokinetic model of the antihelmintic drug, albendazole, and identify the factors influencing the pharmacokinetic parameters in patients with neurocysticercosis. Methods: A prospective study was performed...
6.
Ahn J, Cloyd J, Brundage R, Marino S, Conway J, Ramsay R, et al.
Neurology
. 2008 Jul;
71(1):38-43.
PMID: 18591503
Background: Phenytoin (PHT) is widely used to treat epilepsy in elderly patients, but information on its pharmacokinetics in this population is limited. Objective: The purpose of this study was to...
7.
Fletcher C, Brundage R, Fenton T, Alvero C, Powell C, Mofenson L, et al.
Clin Pharmacol Ther
. 2007 Jul;
83(2):300-6.
PMID: 17609682
Fifty human immunodeficiency virus (HIV)-infected children participated in an area-under-the plasma concentration-time curve (AUC)-controlled trial of efavirenz and nelfinavir. Pharmacokinetic evaluations were performed at weeks 2, 6, and 56. Efavirenz...
8.
Acosta E, Brundage R, King J, Sanchez P, Sood S, Agrawal V, et al.
Clin Pharmacol Ther
. 2007 Mar;
81(6):867-72.
PMID: 17392728
Cytomegalovirus (CMV) is the most common viral congenital infection, producing both sensorineural hearing loss and mental retardation. Our objective was to assess the population pharmacokinetics of a research-grade oral valganciclovir...
9.
Jacobson P, Ng J, Ratanatharathorn V, Uberti J, Brundage R
Bone Marrow Transplant
. 2002 Jan;
28(8):753-8.
PMID: 11781626
Tacrolimus is an immunosuppressant commonly used in the prevention of graft-versus-host disease (GVHD) following allogeneic HCT. Unfortunately, the use of tacrolimus is associated with variable immunosuppression and toxicity. The purpose...
10.
Kline M, Brundage R, Fletcher C, Schwarzwald H, Calles N, Buss N, et al.
Pediatr Infect Dis J
. 2001 Jul;
20(7):666-71.
PMID: 11465838
Objectives: To evaluate the pharmacokinetics, tolerance, safety and antiviral activity of the HIV protease inhibitor, saquinavir, formulated as soft gelatin capsules (SQV-SGC), given in combination with nucleoside antiretroviral agents (NRTIs)...