R M Perlmutter
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Explore the profile of R M Perlmutter including associated specialties, affiliations and a list of published articles.
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118
Citations
4711
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Recent Articles
1.
Sauer K, Liou J, Singh S, Yablonski D, Weiss A, Perlmutter R
J Biol Chem
. 2001 Aug;
276(48):45207-16.
PMID: 11487585
B cell linker protein (BLNK) is a SLP-76-related adaptor protein essential for signal transduction from the BCR. To identify components of BLNK-associated signaling pathways, we performed a phosphorylation-dependent yeast two-hybrid...
2.
Doerfler P, Shearman M, Perlmutter R
Proc Natl Acad Sci U S A
. 2001 Jul;
98(16):9312-7.
PMID: 11470902
In neuronal cells, presenilin-dependent gamma-secretase activity cleaves amyloid precursor proteins to release Abeta peptides, and also catalyzes the release of the intracellular domain of the transmembrane receptor Notch. Accumulation of...
3.
Yamada A, Takaki S, Hayashi F, Georgopoulos K, Perlmutter R, Takatsu K
J Biol Chem
. 2001 Mar;
276(21):18082-9.
PMID: 11278409
The lck gene encodes a protein-tyrosine kinase that plays a key role in signaling mediated through T cell receptor (TCR) and pre-TCR complexes. Transcription of the lck gene is regulated...
4.
Sohn S, Forbush K, Pan X, Perlmutter R
J Immunol
. 2001 Feb;
166(4):2209-17.
PMID: 11160274
p56(lck) is a protein tyrosine kinase expressed throughout T cell development. It associates noncovalently with the cytoplasmic domains of the CD4 and CD8 coreceptor molecules and has been implicated in...
5.
Doerfler P, Forbush K, Perlmutter R
J Immunol
. 2001 Feb;
164(8):4071-9.
PMID: 10754300
Caspases, a family of cysteine proteases, are critical mediators of apoptosis. To address the importance of caspases in thymocyte development, we have generated transgenic mice that express the baculovirus protein...
6.
Takaki S, Sauer K, Iritani B, Chien S, Ebihara Y, Tsuji K, et al.
Immunity
. 2000 Dec;
13(5):599-609.
PMID: 11114373
Lnk is an SH2 domain-containing adaptor protein expressed preferentially in lymphocytes. To illuminate the importance of Lnk, we generated lnk(-/-) mice. Whereas T cell development was unaffected, pre-B and immature...
7.
Farrar M, Olson S, Perlmutter R
Methods Enzymol
. 2000 Oct;
327:421-9.
PMID: 11045000
No abstract available.
8.
Farrar M, Tian J, Perlmutter R
J Biol Chem
. 2000 Jul;
275(40):31318-24.
PMID: 10913130
We have previously described a small molecule-directed protein dimerization strategy, using coumermycin to juxtapose Raf fusion proteins containing the coumermycin-binding domain GyrB. Oligomerization of cytoplasmically localized Raf-GyrB fusion proteins leads...
9.
Seavitt J, White L, Murphy K, Loh D, Perlmutter R, Thomas M
Mol Cell Biol
. 1999 May;
19(6):4200-8.
PMID: 10330160
Mice deficient in the transmembrane protein tyrosine phosphatase CD45 exhibit a block in thymocyte development. To determine whether the block in thymocyte development was due to the inability to dephosphorylate...
10.
Page S, Bogatzki L, Hamerman J, Malissen M, Perlmutter R, Pullen A
Int Immunol
. 1999 Mar;
11(2):169-77.
PMID: 10069415
A pre-TCR-CD3 signal is required for the efficient maturation of CD4- CD8- thymocytes to the CD4+ CD8+ stage. This study addressed whether a similar signal is required for maturation of...