R L Simmer
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Explore the profile of R L Simmer including associated specialties, affiliations and a list of published articles.
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16
Citations
366
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Recent Articles
1.
Stoll V, Qin W, Stewart K, Jakob C, Park C, Walter K, et al.
Bioorg Med Chem
. 2002 Jun;
10(8):2803-6.
PMID: 12057670
The crystal structure of ABT-378 (lopinavir), bound to the active site of HIV-1 protease is described. A comparison with crystal structures of ritonavir, A-78791, and BILA-2450 shows some analogous features...
2.
Luo Y, Kroeger P, Frost L, Chen Z, Han E, Ng S, et al.
Neoplasia
. 2001 Nov;
3(5):411-9.
PMID: 11687952
Checkpoint kinase 1 (Chk1) is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates the Cdc2 activating phosphatase Cdc25C. This in turn inactivates Cdc2, which leads...
3.
Luo Y, Joseph M, Bradner J, Butler C, Tahir S, Han E, et al.
Anticancer Res
. 2001 Apr;
21(1A):23-8.
PMID: 11299740
Background: Chkl is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates Cdc25C at the late G2 phase. The inactivation of Cdc25C and consequently, the inactivation...
4.
McNally T, Helfrich R, Cowart M, Dorwin S, Meuth J, Idler K, et al.
Biochem Biophys Res Commun
. 1997 Feb;
231(3):645-50.
PMID: 9070863
Adenosine kinase is ubiquitous in eukaryotes and is a key enzyme in the regulation of the intracellular levels of adenosine, an important physiological effector of many cells and tissues. In...
5.
Theriault Y, Logan T, Meadows R, Yu L, Olejniczak E, Holzman T, et al.
Nature
. 1993 Jan;
361(6407):88-91.
PMID: 8421500
Cyclosporin A, a cyclic undecapeptide, is a potent immunosuppressant that binds to a peptidyl-prolyl cis-trans isomerase of 165 amino acids, cyclophilin. The cyclosporin A/cyclophilin complex inhibits the calcium- and calmodulin-dependent...
6.
Holzman T, Egan D, Edalji R, Simmer R, Helfrich R, Taylor A, et al.
J Biol Chem
. 1991 Feb;
266(4):2474-9.
PMID: 1989998
We report the cloning of a neutral isoelectric form of the human peptidyl prolyl isomerase, cyclophilin, its expression in Escherichia coli, and its purification and comparison to bovine thymus cyclophilin....
7.
Rittenhouse J, Turon M, Helfrich R, Albrecht K, Weigl D, Simmer R, et al.
Biochem Biophys Res Commun
. 1990 Aug;
171(1):60-6.
PMID: 2203350
A procedure is described which employs pepstatin-agarose for the affinity purification of either HIV-1 or HIV-2 protease from two similar recombinant E. coli constructs that were developed for the expression...
8.
Thompson J, PANDE H, Paxton R, Shively L, Padma A, Simmer R, et al.
Proc Natl Acad Sci U S A
. 1987 May;
84(9):2965-9.
PMID: 3033672
Carcinoembryonic antigen (CEA) is a glycoprotein important as a tumor marker for colonic cancer. Immunological and biochemical studies have shown it to be closely related to a number of other...
9.
Singer-Sam J, Keith D, Tani K, Simmer R, Shively L, Lindsay S, et al.
Gene
. 1984 Dec;
32(3):409-17.
PMID: 6099325
We have determined the sequence of an 812-bp BamHI-EcoRI restriction fragment containing the 5' region of the human gene for PGK (3-phosphoglycerate kinase or ATP:3-phospho-D-glycerate 1-phosphotransferase; EC 2.7.2.3). The fragment...
10.
Singer-Sam J, Simmer R, Keith D, Shively L, Teplitz M, Itakura K, et al.
Proc Natl Acad Sci U S A
. 1983 Feb;
80(3):802-6.
PMID: 6572369
We have obtained a cDNA clone encoding most of human X-linked 3-phosphoglycerate kinase (PGK; ATP:3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3). Total mRNA was prepared from human adenocarcinoma-derived cell line LS174T and used...