R John Solaro
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Explore the profile of R John Solaro including associated specialties, affiliations and a list of published articles.
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223
Citations
6012
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Recent Articles
1.
Wang X, Solaro R, Dong W
J Mol Cell Cardiol
. 2025 Mar;
PMID: 40073932
Sarcomere length-dependent activation (LDA) is essential to engaging the Frank-Starling mechanism in the beat-to-beat regulation of cardiac output. Through LDA, the heart increases the Ca sensitivity of myocardial contraction at...
2.
Wang X, Kallish N, Solaro R, Dong W
J Mol Cell Cardiol
. 2025 Mar;
202:24-34.
PMID: 40068771
Sarcomere length-dependent activation (LDA) is the key cellular mechanism underlying the Frank-Starling law of the heart, in which sarcomere stretch leads to increased Ca sensitivity of myofilament and force of...
3.
Rosas P, Solaro R
Compr Physiol
. 2025 Mar;
15(2):e70006.
PMID: 40065530
This review focuses on p21-activated kinase 1 (Pak1), a multifunctional, highly conserved enzyme that regulates multiple downstream effectors present in many tissues. Upstream signaling via Ras-related small G-proteins, Cdc42/Rac1 promotes...
4.
Langa P, Wolska B, Solaro R
Int J Drug Discov Pharm
. 2024 May;
1(1).
PMID: 38818406
We focus here on the Hippo pathway in the hierarchical sensing and modulation of the mechanical state of the adult heart in health and disease. The Hippo pathway interrogates the...
5.
Solaro R, Goldspink P, Wolska B
Biomedicines
. 2024 May;
12(5).
PMID: 38790961
Novel therapies for the treatment of familial dilated cardiomyopathy (DCM) are lacking. Shaping research directions to clinical needs is critical. Triggers for the progression of the disorder commonly occur due...
6.
Perike S, Gonzalez-Gonzalez F, Abu-Taha I, Damen F, Hanft L, Lizama K, et al.
Circ Res
. 2023 Sep;
133(9):758-771.
PMID: 37737016
Background: Atrial fibrillation (AF)-the most common sustained cardiac arrhythmia-increases thromboembolic stroke risk 5-fold. Although atrial hypocontractility contributes to stroke risk in AF, the molecular mechanisms reducing myofilament contractile function remain...
7.
Shafaattalab S, Li A, Jayousi F, Maaref Y, Dababneh S, Hamledari H, et al.
bioRxiv
. 2023 Aug;
PMID: 37609317
Hypertrophic cardiomyopathy (HCM) is one of the most common heritable cardiovascular diseases and variants of (cardiac troponin T) are linked to increased risk of sudden cardiac arrest despite causing limited...
8.
Phillips E, Bindokas V, Jung D, Teamer J, Kitajewski J, Solaro R, et al.
Microcirculation
. 2023 Aug;
30(7):e12826.
PMID: 37605603
Objective: Three-dimensional (3D) microscopy and image data analysis are necessary for studying the morphology of cardiac lymphatic vessels (LyVs) and their association with other cell types. We aimed to develop...
9.
Solis C, Warren C, Dittloff K, DiNello E, Solaro R, Russell B
FEBS J
. 2023 Aug;
290(22):5322-5339.
PMID: 37551968
Loss of myocardial mass in a neonatal rat cardiomyocyte culture is studied to determine whether there is a distinguishable cellular response based on the origin of mechano-signals. The approach herein...
10.
Perike S, Gonzalez-Gonzalez F, Abu-Taha I, Damen F, Lizama K, Aboonabi A, et al.
bioRxiv
. 2023 May;
PMID: 37131731
Background: Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, increases thromboembolic stroke risk five-fold. Although atrial hypocontractility contributes to stroke risk in AF, the molecular mechanisms reducing myofilament contractile...