Tomoyoshi Kobayashi
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Explore the profile of Tomoyoshi Kobayashi including associated specialties, affiliations and a list of published articles.
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34
Citations
1395
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Recent Articles
1.
Genchev G, Kobayashi M, Kobayashi T, Lu H
FEBS Open Bio
. 2020 Oct;
11(7):1841-1853.
PMID: 33085832
Understanding the regulation of cardiac muscle contraction at a molecular level is crucial for the development of therapeutics for heart conditions. Despite the availability of atomic structures of the protein...
2.
Johnson D, Mathur M, Kobayashi T, Chalovich J
Biochemistry
. 2016 Jul;
55(32):4533-40.
PMID: 27454189
The R146G mutation of troponin I (TnI) is associated with hypertrophic cardiomyopathy in humans. Earlier data pointed to stabilization of the intermediate, C state, of actin-tropomyosin-troponin by this mutant. Because...
3.
Warren C, Karam C, Wolska B, Kobayashi T, de Tombe P, Arteaga G, et al.
Circ Cardiovasc Genet
. 2015 Nov;
8(6):765-73.
PMID: 26553696
Background: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease characterized by thickening of ventricular walls and decreased left ventricular chamber volume. The majority of HCM-associated mutations are found...
4.
Kobayashi M, Debold E, Turner M, Kobayashi T
J Biol Chem
. 2013 Jul;
288(36):26335-26349.
PMID: 23897817
The striated muscle thin filament comprises actin, tropomyosin, and troponin. The Tn complex consists of three subunits, troponin C (TnC), troponin I (TnI), and troponin T (TnT). TnT may serve...
5.
Yar S, Chowdhury S, Davis 3rd R, Kobayashi M, Monasky M, Rajan S, et al.
J Biol Chem
. 2013 Apr;
288(23):16235-16246.
PMID: 23609439
α-Tropomyosin (α-TM) has a conserved, charged Asp-137 residue located in the hydrophobic core of its coiled-coil structure, which is unusual in that the residue is found at a position typically...
6.
Genchev G, Kobayashi T, Lu H
PLoS One
. 2013 Apr;
8(3):e58313.
PMID: 23554884
The interaction between calcium and the regulatory site(s) of striated muscle regulatory protein troponin switches on and off muscle contraction. In skeletal troponin binding of calcium to sites I and...
7.
Solaro R, Henze M, Kobayashi T
Circ Res
. 2013 Jan;
112(2):355-66.
PMID: 23329791
We focus here on the modulation of thin filament activity by cardiac troponin I phosphorylation as an integral and adaptive mechanism in cardiac homeostasis and as a mechanism vulnerable to...
8.
Henze M, Patrick S, Hinken A, Scruggs S, Goldspink P, de Tombe P, et al.
Biochim Biophys Acta
. 2012 Sep;
1833(4):823-32.
PMID: 22940544
Previous structural studies indicated a special functional role for an acidic region composed of residues 1-10 in the unique N-terminal peptide of cardiac troponin I (cTnI). Employing LC-MS/MS, we determined...
9.
Franklin A, Baxley T, Kobayashi T, Chalovich J
Biophys J
. 2012 Jun;
102(11):2536-44.
PMID: 22713569
Striated muscle contraction is regulated by the actin binding proteins tropomyosin and troponin. Defects in these proteins lead to myopathies and cardiomyopathies. Deletion of the 14 C-terminal residues of cardiac...
10.
Solaro R, Kobayashi T
J Biol Chem
. 2011 Jan;
286(12):9935-40.
PMID: 21257760
No abstract available.