R J Coffey Jr
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Explore the profile of R J Coffey Jr including associated specialties, affiliations and a list of published articles.
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52
Citations
1918
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Recent Articles
1.
Denning M, Dlugosz A, Cheng C, Dempsey P, Coffey Jr R, Threadgill D, et al.
Exp Dermatol
. 2000 Jun;
9(3):192-9.
PMID: 10839717
The induction of epidermal differentiation by extracellular Ca2+ involves activation of both tyrosine kinase and protein kinase C (PKC) signaling cascades. To determine if the differentiation-dependent activation of tyrosine kinase...
2.
Song S, Gannon M, Washington M, Scoggins C, Meszoely I, Goldenring J, et al.
Gastroenterology
. 1999 Dec;
117(6):1416-26.
PMID: 10579983
Background & Aims: The progenitor cells responsible for transforming growth factor (TGF)-alpha-induced pancreatic ductal metaplasia and neoplasia remain uncharacterized. During pancreatic development, differentiated cell types arise from ductal progenitor cells...
3.
Lee H, Udupi V, Englander E, Rajaraman S, Coffey Jr R, Greeley Jr G
Endocrinology
. 1999 Aug;
140(9):4065-9.
PMID: 10465277
Proliferation of the gastrointestinal mucosa is stimulated by the growth factors, insulin-like growth factor-I (IGF-I) and transforming growth factor-alpha (TGF-alpha), or the closely related epidermal growth factor (EGF), as well...
4.
Damstrup L, Kuwada S, Dempsey P, Brown C, Hawkey C, Poulsen H, et al.
Br J Cancer
. 1999 Jun;
80(7):1012-9.
PMID: 10362109
Colonic enterocytes, like many epithelial cells in vivo, are polarized with functionally distinct apical and basolateral membrane domains. The aims of this study were to characterize the endogenous epidermal growth...
5.
Norgaard P, Law B, Joseph H, Page D, Shyr Y, Mays D, et al.
Clin Cancer Res
. 1999 Jan;
5(1):35-42.
PMID: 9918200
Mouse mammary tumor virus-transforming growth factor alpha (MMTV-TGF alpha) and MMTV-TGF alpha/neu transgenic mice develop mammary tumors after a long latency and therefore provide useful model systems for breast cancer...
6.
Oldham S, Cox A, Reynolds E, Sizemore N, Coffey Jr R, Der C
Oncogene
. 1998 Jun;
16(20):2565-73.
PMID: 9632133
Src transformation of NIH3T3 mouse fibroblasts has been shown to be dependent on Ras function. Since we recently showed that the signaling pathways that mediate Ras transformation of RIE-1 rat...
7.
Sheng G, Shao J, Sheng H, Hooton E, Isakson P, Morrow J, et al.
Gastroenterology
. 1997 Dec;
113(6):1883-91.
PMID: 9394727
Background & Aims: Constitutive expression of cyclooxygenase 2 (COX-2) has been found in 85% of colorectal cancers. Ras mutations are found in 50% of colorectal adenocarcinomas. The aim of this...
8.
Dlugosz A, Hansen L, Cheng C, Alexander N, Denning M, Threadgill D, et al.
Cancer Res
. 1997 Aug;
57(15):3180-8.
PMID: 9242447
We have assessed the role of epidermal growth factor receptor (EGFR) signaling in biological responses to the v-ras(Ha) oncogene using primary keratinocytes from Egfr -/- mice and wild-type littermates. On...
9.
Zhang R, Zhang H, Zhu W, Pardee A, Coffey Jr R, Liang P
Oncogene
. 1997 Apr;
14(13):1607-10.
PMID: 9129152
Mutations in the ras oncogenes have been linked to many different cancers. In contrast to the extensive body of knowledge related to the genetics of ras activation, relatively little is...
10.
Oldham S, Clark G, Gangarosa L, Coffey Jr R, Der C
Proc Natl Acad Sci U S A
. 1996 Jul;
93(14):6924-8.
PMID: 8692920
The potent transforming activity of membrane-targeted Raf-1 (Raf-CAAX) suggests that Ras transformation is triggered primarily by a Ras-mediated translocation of Raf-1 to the plasma membrane. However, whereas constitutively activated mutants...