R Derynck
Overview
Explore the profile of R Derynck including associated specialties, affiliations and a list of published articles.
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Articles
155
Citations
11379
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Recent Articles
1.
Habig M, Smola H, Dole V, Derynck R, Pfister H, Smola-Hess S
Arch Virol
. 2006 May;
151(10):1961-72.
PMID: 16710631
Human papillomaviruses (HPV) infect keratinocytes of skin and mucosa. Persistent infection can lead to the formation of benign tumors. In cases of high-risk HPV, such as HPV16 or 18, these...
2.
Roberts A, Derynck R
Sci STKE
. 2001 Dec;
2001(113):pe43.
PMID: 11752631
The transforming growth factor-beta (TGF-beta) superfamily of signaling molecules regulates many developmental processes in a range of organisms from worms to humans. Understanding the mechanisms by which they exert their...
3.
Liu D, Black B, Derynck R
Genes Dev
. 2001 Nov;
15(22):2950-66.
PMID: 11711431
Transforming growth factor-beta (TGF-beta) is a potent inhibitor of skeletal muscle differentiation, but the molecular mechanism and signaling events that lead to this inhibition are poorly characterized. Here we show...
4.
Akhurst R, Derynck R
Trends Cell Biol
. 2001 Oct;
11(11):S44-51.
PMID: 11684442
Transforming growth factor (TGF) beta1 is a potent growth inhibitor, with tumor-suppressing activity. Cancers are often refractile to this growth inhibition either because of genetic loss of TGF-beta signaling components...
5.
Derynck R, Akhurst R, Balmain A
Nat Genet
. 2001 Oct;
29(2):117-29.
PMID: 11586292
Epithelial and hematopoietic cells have a high turnover and their progenitor cells divide continuously, making them prime targets for genetic and epigenetic changes that lead to cell transformation and tumorigenesis....
6.
Stoll S, Kansra S, Peshick S, FRY D, Leopold W, Wiesen J, et al.
Neoplasia
. 2001 Sep;
3(4):339-50.
PMID: 11571634
Induction of heparin-binding epidermal growth factor-like growth factor (HB-EGF) mRNA in mouse skin organ culture was blocked by two pan-ErbB receptor tyrosine kinase (RTK) inhibitors but not by genetic ablation...
7.
8.
Alliston T, Choy L, Ducy P, Karsenty G, Derynck R
EMBO J
. 2001 May;
20(9):2254-72.
PMID: 11331591
Transforming growth factor-beta (TGF-beta), a secreted factor present at high levels in bone, inhibits osteoblast differentiation in culture; yet, the mechanism of this inhibition remains unclear. We studied the effects...
9.
Zhang Y, Chang C, Gehling D, Hemmati-Brivanlou A, Derynck R
Proc Natl Acad Sci U S A
. 2001 Feb;
98(3):974-9.
PMID: 11158580
Smad proteins are key intracellular signaling effectors for the transforming growth factor-beta superfamily of peptide growth factors. Following receptor-induced activation, Smads move into the nucleus to activate transcription of a...
10.
Kuo A, Zhong C, Lane W, Derynck R
EMBO J
. 2000 Dec;
19(23):6427-39.
PMID: 11101516
Transforming growth factor-alpha (TGF-alpha) and related proteins represent a family of transmembrane growth factors with representatives in flies and worms. Little is known about the transport of TGF-alpha and other...