R Horuk
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Explore the profile of R Horuk including associated specialties, affiliations and a list of published articles.
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99
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4028
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Recent Articles
11.
Horuk R, Clayberger C, Krensky A, Wang Z, Grone H, Weber C, et al.
J Biol Chem
. 2000 Oct;
276(6):4199-204.
PMID: 11054419
Chemokines like RANTES appear to play a role in organ transplant rejection. Because RANTES is a potent agonist for the chemokine receptor CCR1, we examined whether the CCR1 receptor antagonist...
12.
Puffer B, Sharron M, Coughlan C, Baribaud F, McManus C, Lee B, et al.
Virology
. 2000 Oct;
276(2):435-44.
PMID: 11040134
APJ is a seven transmembrane domain G-protein-coupled receptor that functions as a coreceptor for some primate immunodeficiency virus strains. The in vivo significance of APJ coreceptor function remains to be...
13.
Horuk R, Ng H
Med Res Rev
. 2000 Mar;
20(2):155-68.
PMID: 10723026
Chemokines belong to a large family of chemoattractant molecules involved in the directed migration of immune cells. They achieve their cellular effects by direct interaction with cell surface receptors. Chemokines...
14.
Murphy P, Baggiolini M, Charo I, Hebert C, Horuk R, Matsushima K, et al.
Pharmacol Rev
. 2000 Mar;
52(1):145-76.
PMID: 10699158
Chemokine receptors comprise a large family of seven transmembrane domain G protein-coupled receptors differentially expressed in diverse cell types. Biological activities have been most clearly defined in leukocytes, where chemokines...
15.
Liang M, Rosser M, Ng H, May K, Bauman J, Islam I, et al.
Eur J Pharmacol
. 2000 Feb;
389(1):41-9.
PMID: 10686294
The species specificity of a small molecule antagonist for the human CCR1 chemokine receptor, 2-2-diphenyl-5-(4-chlorophenyl)piperidin-1-yl)valeronitrile (CCR1 antagonist 1), has been examined using cloned CCR1 receptors from various species. The compound...
16.
Molino M, Woolkalis M, Prevost N, Pratico D, Barnathan E, Taraboletti G, et al.
Biochim Biophys Acta
. 2000 Feb;
1500(2):227-40.
PMID: 10657592
It has been shown that deletion of the chemokine receptor, CXCR4, causes disordered angiogenesis in mouse models. In the present studies, we examined the distribution and trafficking of CXCR4 in...
17.
Ng H, May K, Bauman J, Ghannam A, Islam I, Liang M, et al.
J Med Chem
. 1999 Dec;
42(22):4680-94.
PMID: 10579830
Ligands for the CCR1 receptor (MIP-1alpha and RANTES) have been implicated in a number of chronic inflammatory diseases, most notably multiple sclerosis and rheumatoid arthritis. Because these ligands share a...
18.
Hesselgesser J, Horuk R
J Neurovirol
. 1999 Apr;
5(1):13-26.
PMID: 10190686
A decade ago several new cytokines were described that orchestrated the activation and migration of immune cells. These newly described cytokines, of which interleukin-8 (IL-8) was a representative member, defined...
19.
Horuk R
Immunol Today
. 1999 Mar;
20(2):89-94.
PMID: 10098328
Chemokines mediate their effects by binding to cell-surface receptors that belong to the seven-transmembrane-domain superfamily of proteins. Chemokine receptors have been subject to intense scrutiny following the recent discovery that...
20.
Baly D, Horuk R, Yansura D, Simmons L, Fairbrother W, Kotts C, et al.
J Immunol
. 1998 Oct;
161(9):4944-9.
PMID: 9794430
Melanoma growth stimulating activity (MGSA) and IL-8 are related chemokines that are potent chemoattractants and activators of neutrophils both in vitro and in vivo. Increasing evidence suggests that these molecules...