R Grumont
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Explore the profile of R Grumont including associated specialties, affiliations and a list of published articles.
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9
Citations
461
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Recent Articles
1.
Gerondakis S, Grumont R, Gugasyan R, Wong L, Isomura I, Ho W, et al.
Oncogene
. 2006 Oct;
25(51):6781-99.
PMID: 17072328
The nuclear factor-kappaB (NF-kappaB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we...
2.
Grumont R, HOCHREIN H, OKeeffe M, Gugasyan R, White C, Caminschi I, et al.
J Exp Med
. 2001 Oct;
194(8):1021-32.
PMID: 11602633
Interleukin 12 (IL-12) is a 70-kD proinflammatory cytokine produced by antigen presenting cells that is essential for the induction of T helper type 1 development. It comprises 35-kD (p35) and...
3.
Gugasyan R, Grumont R, Grossmann M, Nakamura Y, Pohl T, Nesic D, et al.
Immunol Rev
. 2000 Oct;
176:134-40.
PMID: 11043773
The Rel/nuclear factor (NF)-kappaB family of transcription factors have been implicated in the regulation of a wide variety of genes, in particular those encoding proteins crucial to the function of...
4.
Gerondakis S, Grossmann M, Nakamura Y, Pohl T, Grumont R
Oncogene
. 1999 Dec;
18(49):6888-95.
PMID: 10602464
Rel/NF-kappaB transcription factors have been implicated in regulating a wide variety of genes important in cellular processes that include cell division, cell survival, differentiation and immunity. Here genetic models in...
5.
Grossmann M, Nakamura Y, Grumont R, Gerondakis S
Int J Biochem Cell Biol
. 1999 Dec;
31(10):1209-19.
PMID: 10582348
In mammals, Rel/NF-kappa B proteins are a small family of transcription factors which serve as pivotal regulators of immune, inflammatory and acute phase responses. Pathways leading to the activation of...
6.
Gerondakis S, Grumont R, Rourke I, Grossmann M
Curr Opin Immunol
. 1998 Jun;
10(3):353-9.
PMID: 9638373
The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear...
7.
Grumont R, Sirawaraporn W, Santi D
Biochemistry
. 1988 May;
27(10):3776-84.
PMID: 2841973
The bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) of Leishmania major has been cloned and expressed in Escherichia coli and Saccharomyces cerevisiae. The strategy involved placing the entire 1560-bp coding sequence into...
8.
Grumont R, Washtien W, Caput D, Santi D
Proc Natl Acad Sci U S A
. 1986 Aug;
83(15):5387-91.
PMID: 3461439
In protozoa, thymidylate synthase (TS; EC 2.1.1.45) and dihydrofolate reductase (DHFR; EC 1.5.1.3) exist as a bifunctional protein. Full-length cDNA and genomic DNA clones encoding the bifunctional TS-DHFR from Leishmania...
9.
Washtien W, Grumont R, Santi D
J Biol Chem
. 1985 Jul;
260(13):7809-12.
PMID: 2409075
Leishmania tropica promastigotes selected for resistance to the dihydrofolate reductase inhibitor, methotrexate, or the thymidylate synthase inhibitor, 5,8-dideaza-10-propargyl folate, overproduce a bifunctional thymidylate synthase-dihydrofolate reductase and possess a 30-kilobase region...