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S Gerondakis

Explore the profile of S Gerondakis including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 56
Citations 2209
Followers 0
Related Specialties
Allergy & Immunology
Cell Biology
Molecular Biology
Top 10 Co-Authors
R J Grumont
J M Adams
A Strasser
S Cory
E Webb
O Bernard
R Gugasyan
R Grumont
M Grossmann
C Gaff
Published In
Proc Natl Acad Sci U S A
EMBO J
Int Immunol
Cell Growth Differ
Cell Death Differ
Affiliations
Soon will be listed here.
Recent Articles
1.
Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice
Low J, Hughes P, Lin A, Siebenlist U, Jain R, Yaprianto K, et al.
Immunol Cell Biol . 2015 Jun; 94(1):66-78. PMID: 26084385
Defects in apoptosis can cause autoimmune disease. Loss-of-function mutations in the 'death receptor' FAS impair the deletion of autoreactive lymphocytes in the periphery, leading to progressive lymphadenopathy and systemic lupus...
2.
Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation
OReilly L, Hughes P, Lin A, Waring P, Siebenlist U, Jain R, et al.
Cell Death Differ . 2014 Nov; 22(5):767-78. PMID: 25361085
FASL/FAS signaling imposes a critical barrier against autoimmune disease and lymphadenopathy. Mutant mice unable to produce membrane-bound FASL (FasL(Δm/Δm)), a prerequisite for FAS-induced apoptosis, develop lymphadenopathy and systemic autoimmune disease...
3.
MEK inhibitors as a chemotherapeutic intervention in multiple myeloma
Chang-Yew Leow C, Gerondakis S, Spencer A
Blood Cancer J . 2013 Mar; 3:e105. PMID: 23524590
The Ras/Raf/MEK/extracellular signal regulated kinase (ERK) (Ras/mitogen-activated protein kinases (MAPK)) signal transduction pathway is a crucial mediator of many fundamental biological processes, including cellular proliferation, survival, angiogenesis and migration. Aberrant...
4.
Loss of the BH3-only protein Bid does not rescue RelA-deficient embryos from TNF-R1-mediated fatal hepatocyte destruction
Kaufmann T, Gugasyan R, Gerondakis S, Dixit V, Strasser A
Cell Death Differ . 2006 Nov; 14(3):637-9. PMID: 17096024
No abstract available.
5.
Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models
Gerondakis S, Grumont R, Gugasyan R, Wong L, Isomura I, Ho W, et al.
Oncogene . 2006 Oct; 25(51):6781-99. PMID: 17072328
The nuclear factor-kappaB (NF-kappaB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we...
6.
Bcl-2 transgene expression fails to prevent fatal hepatocyte apoptosis induced by endogenous TNFalpha in mice lacking RelA
Gugasyan R, Christou A, OReilly L, Strasser A, Gerondakis S
Cell Death Differ . 2006 Feb; 13(7):1235-7. PMID: 16485035
No abstract available.
7.
PU.1/Spi-B regulation of c-rel is essential for mature B cell survival
Hu C, Rao S, Gerondakis S, Clark M, Simon M
Immunity . 2001 Oct; 15(4):545-55. PMID: 11672537
PU.1(+/-)Spi-B(-/-) mice exhibit reduced numbers of immature and mature B lymphocytes, which exhibit severe defects in response to BCR-mediated stimulation and poor survival. We found that expression of c-rel, a...
8.
c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription
Grumont R, HOCHREIN H, OKeeffe M, Gugasyan R, White C, Caminschi I, et al.
J Exp Med . 2001 Oct; 194(8):1021-32. PMID: 11602633
Interleukin 12 (IL-12) is a 70-kD proinflammatory cytokine produced by antigen presenting cells that is essential for the induction of T helper type 1 development. It comprises 35-kD (p35) and...
9.
To live and let die
Gerondakis S, Strasser A
Nat Immunol . 2001 Apr; 2(5):377-9. PMID: 11323685
No abstract available.
10.
NF-kappa B RelA (p65) is essential for TNF-alpha-induced fas expression but dispensable for both TCR-induced expression and activation-induced cell death
Zheng Y, Ouaaz F, Bruzzo P, Singh V, Gerondakis S, Beg A
J Immunol . 2001 Apr; 166(8):4949-57. PMID: 11290773
The Fas death receptor plays a key role in the killing of target cells by NK cells and CTLs and in activation-induced cell death of mature T lymphocytes. These cytotoxic...