R G Tirona
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Explore the profile of R G Tirona including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
409
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0
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Recent Articles
1.
Silveira C, MacKinley J, Coleman K, Li Z, Finger E, Bartha R, et al.
BMC Neurol
. 2019 Feb;
19(1):20.
PMID: 30738426
Background: Currently there are no disease-modifying treatments for Parkinson's disease dementia (PDD), a condition linked to aggregation of the protein α-synuclein in subcortical and cortical brain areas. One of the...
2.
DeGorter M, Urquhart B, Gradhand U, Tirona R, Kim R
J Clin Pharmacol
. 2011 Dec;
52(11):1689-97.
PMID: 22167570
Response to statin therapy is often unpredictable because of variability in metabolism and transport. In the recently created organic anion transporting-polypeptide 1b2 (Oatp1b2/Slco1b2)-null mice, the investigators found significantly lower liver-to-plasma...
3.
Eechoute K, Franke R, Loos W, Scherkenbach L, Boere I, Verweij J, et al.
Clin Pharmacol Ther
. 2011 Apr;
89(6):816-20.
PMID: 21508937
The bioavailability of orally administered imatinib is >90%, although the drug is monocationic under the acidic conditions in the duodenum. In vitro, we found that imatinib is transported by the...
4.
Cutler M, Urquhart B, Velenosi T, Meyer Zu Schwabedissen H, Dresser G, Leake B, et al.
J Clin Pharmacol
. 2011 Apr;
52(4):530-42.
PMID: 21505084
Mesna and its dimer, dimesna, are coadministered for mitigation of ifosfamide- and cisplatin-induced toxicities, respectively. Dimesna is selectively reduced to mesna in the kidney, producing its protective effects. In vitro...
5.
Glaeser H, Bailey D, Dresser G, Gregor J, Schwarz U, McGrath J, et al.
Clin Pharmacol Ther
. 2007 Jan;
81(3):362-70.
PMID: 17215845
The goals of this study were to assess the extent of human intestinal drug transporter expression, determine the subcellular localization of the drug uptake transporter OATP1A2, and then to assess...
6.
Tirona R, Leake B, Merino G, Kim R
J Biol Chem
. 2001 Jul;
276(38):35669-75.
PMID: 11477075
The human organic anion transporting polypeptide-C (OATP-C) (gene SLC21A6) is a liver-specific transporter importantly involved in the hepatocellular uptake of a variety of endogenous and foreign chemicals. In this study,...
7.
Tirona R, Tan E, Meier G, Pang K
J Pharmacol Exp Ther
. 1999 Nov;
291(3):1210-9.
PMID: 10565844
We assessed the impact of zonal factors on the hepatic reduced glutathione (GSH) conjugation of ethacrynic acid (EA). Uptake of EA by enriched periportal (PP) and perivenous (PV) rat hepatocytes...
8.
Tirona R, Pang K
J Pharmacol Exp Ther
. 1999 Aug;
290(3):1230-41.
PMID: 10454499
The conjugation kinetics of glutathione (GSH) and ethacrynic acid (EA) were studied in rat liver perfusion studies, where efficient removal occurred (steady-state extraction ratio E(ss), approximately 0.8-0.4 at concentrations ranging...
9.
Tan E, Tirona R, Pang K
Drug Metab Dispos
. 1999 Mar;
27(3):336-41.
PMID: 10064563
The zonal uptake of estrone sulfate (E1S; 1 to 400 microM) was investigated in periportal and perivenous rat hepatocytes and cells isolated from whole liver (regular hepatocytes). Transport of E1S...
10.
Tirona R, Schwab A, Geng W, Pang K
Drug Metab Dispos
. 1998 Jun;
26(5):465-75.
PMID: 9571228
The multiple indicator dilution (MID) technique is often used for investigation of the kinetic behavior of substrates and metabolites in eliminating organs. The present study was a systematic comparison of...