G K Dresser
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Explore the profile of G K Dresser including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
755
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Recent Articles
1.
Al-Judaibi B, Schwarz U, Huda N, Dresser G, Gregor J, Ponich T, et al.
J Popul Ther Clin Pharmacol
. 2016 Mar;
23(1):e26-36.
PMID: 26950049
Background: Thiopurines (Azathioprine (AZA) and 6-Mercaptopurine (6-MP) are considered a well-established therapy for patients with Inflammatory Bowel Disease (IBD) including ulcerative colitis (UC) and Crohn's Disease (CD). However, nearly 20%...
2.
Cutler M, Urquhart B, Velenosi T, Meyer Zu Schwabedissen H, Dresser G, Leake B, et al.
J Clin Pharmacol
. 2011 Apr;
52(4):530-42.
PMID: 21505084
Mesna and its dimer, dimesna, are coadministered for mitigation of ifosfamide- and cisplatin-induced toxicities, respectively. Dimesna is selectively reduced to mesna in the kidney, producing its protective effects. In vitro...
3.
Schwarz U, Hanso H, Oertel R, Miehlke S, Kuhlisch E, Glaeser H, et al.
Clin Pharmacol Ther
. 2007 Mar;
81(5):669-78.
PMID: 17392718
St John's wort (SJW) is known to induce cytochrome P450 (CYP) 3A4 and P-glycoprotein through pregnane X-receptor activation. Our study evaluated the effects of long-term SJW administration on oral and...
4.
Bailey D, Dresser G, Leake B, Kim R
Clin Pharmacol Ther
. 2007 Feb;
81(4):495-502.
PMID: 17301733
We showed previously that grapefruit and orange juices inhibited human enteric organic anion-transporting polypeptide (OATP)1A2 in vitro and lowered oral fexofenadine bioavailability clinically. Inhibition of OATP1A2 transport by flavonoids in...
5.
Glaeser H, Bailey D, Dresser G, Gregor J, Schwarz U, McGrath J, et al.
Clin Pharmacol Ther
. 2007 Jan;
81(3):362-70.
PMID: 17215845
The goals of this study were to assess the extent of human intestinal drug transporter expression, determine the subcellular localization of the drug uptake transporter OATP1A2, and then to assess...
6.
Dresser G, Bailey D
Eur J Clin Invest
. 2003 Dec;
33 Suppl 2:10-6.
PMID: 14641551
Grapefruit juice produces mechanism-based inhibition of intestinal drug metabolism when consumed in normal quantities. This can produce clinically important increases in oral drug bioavailability when coadministered with substrates of cytochrome...
7.
Kurowska E, Dresser G, Deutsch L, Vachon D, Khalil W
Prostaglandins Leukot Essent Fatty Acids
. 2003 Feb;
68(3):207-12.
PMID: 12591004
Increased dietary intake of fish oil omega-3 fatty acids, eicosapentanoic acid and docosohexanoic acid, and their precursor, alpha-linolenic acid (ALA), is associated with various health benefits. Enteric-coating (Entrox), which improves...
8.
Kim R, Leake B, Choo E, Dresser G, Kubba S, Schwarz U, et al.
Clin Pharmacol Ther
. 2001 Aug;
70(2):189-99.
PMID: 11503014
MDR1 (P-glycoprotein) is an important factor in the disposition of many drugs, and the involved processes often exhibit considerable interindividual variability that may be genetically determined. Single-strand conformational polymorphism analysis...
9.
Offman E, Freeman D, Dresser G, Munoz C, Bend J, Bailey D
Clin Pharmacol Ther
. 2001 Jul;
70(1):17-23.
PMID: 11452240
Objectives: Our objective was to compare the interactions of red wine and grapefruit juice with cisapride. Methods: The oral pharmacokinetics of cisapride, its norcisapride metabolite, and electrocardiographic QTc interval were...
10.
Bailey D, Dresser G, Kreeft J, Munoz C, Freeman D, Bend J
Clin Pharmacol Ther
. 2000 Dec;
68(5):468-77.
PMID: 11103749
Objectives: To determine whether unprocessed grapefruit can cause a drug interaction, whether the active ingredients are naturally occurring, and whether specific furanocoumarins or flavonoids are involved. Methods: The oral pharmacokinetics...