R B Cornell
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Explore the profile of R B Cornell including associated specialties, affiliations and a list of published articles.
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31
Citations
578
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Recent Articles
11.
Johnson J, Aebersold R, Cornell R
Biochim Biophys Acta
. 1997 Mar;
1324(2):273-84.
PMID: 9092714
CTP:phosphocholine cytidylyltransferase (CT), the rate controlling enzyme in phosphatidylcholine biosynthesis, is activated by reversible membrane binding. To investigate the membrane binding mechanism of CT, we have used the photoreactive hydrophobic...
12.
Dunne S, Cornell R, Johnson J, Glover N, Tracey A
Biochemistry
. 1996 Sep;
35(37):11975-84.
PMID: 8810902
It has been proposed that the domain of the regulatory enzyme, CTP:phosphocholine cytidylyltransferase, which mediates reversible binding of the enzyme to membranes, is an amphipathic alpha-helix of approximately 60 amino...
13.
Veitch D, Cornell R
Biochemistry
. 1996 Aug;
35(33):10743-50.
PMID: 8718864
The effect of mutations in the proposed catalytic domain of CTP:phosphocholine cytidylyltransferase was investigated by constructing the single mutants CT-S91 and CT-C114 from the double mutant CT-S91C114, previously shown to...
14.
Arnold R, Cornell R
Biochemistry
. 1996 Jul;
35(30):9917-24.
PMID: 8703966
The contributions of electrostatic and hydrophobic interactions in the activation of cytidylyl-transferase (CT) by various negatively charged lipids were analyzed using small unilamellar or multilamellar vesicles (SUVs or MLVs). The...
15.
Cornell R, Kalmar G, Kay R, Johnson M, Sanghera J, Pelech S
Biochem J
. 1995 Sep;
310 ( Pt 2):699-708.
PMID: 7654214
The role of the C-terminal domain of CTP: phosphocholine cytidylyltransferase (CT) was explored by the creation of a series of deletion mutations in rat liver cDNA, which were expressed in...
16.
Kalmar G, Kay R, LaChance A, Cornell R
Biochim Biophys Acta
. 1994 Oct;
1219(2):328-34.
PMID: 7918629
Human CTP:phosphocholine cytidylyltransferase (CT) cDNAs were isolated by PCR amplification of a human erythroleukemic K562 cell library. Initially two degenerate oligonucleotide primers derived from the sequence of the rat liver...
17.
Cornell R, Kerlakian G
Am J Surg
. 1994 Sep;
168(3):275-9.
PMID: 8080067
We conducted a prospective study to evaluate early complications and complaints of 60 patients who underwent laparoscopic transperitoneal hernia repair at our institution. Average follow-up was 9 months. Patients graded...
18.
Johnson J, Cornell R
Biochemistry
. 1994 Apr;
33(14):4327-35.
PMID: 8155650
A peptide corresponding to a portion of the amphipathic alpha-helical region of CTP:phosphocholine cytidylyltransferase was synthesized. This region of the enzyme was proposed to be the membrane-binding domain [Kalmar, G.B.,...
19.
Walkey C, Kalmar G, Cornell R
J Biol Chem
. 1994 Feb;
269(8):5742-9.
PMID: 8119913
Two rat liver cDNAs encoding CTP:phosphocholine cytidylyltransferase (CT-1 and CT-2) were expressed in COS cells. The specific activity of CT in the microsomes increased approximately 20- or 100-fold after transfection...
20.
Craig L, Johnson J, Cornell R
J Biol Chem
. 1994 Feb;
269(5):3311-7.
PMID: 8106370
Limited chymotrypsin proteolysis of CTP:phosphocholine cytidylyltransferase (CT; EC 2.7.7.15) produced several distinct fragments which were mapped to the N terminus of CT using antibodies directed against the N and C...