R A Voskuyl
Overview
Explore the profile of R A Voskuyl including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
322
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Recent Articles
1.
de Lange E, Vd Berg D, Bellanti F, Voskuyl R, Syvanen S
Eur J Pharm Sci
. 2018 Aug;
124:61-70.
PMID: 30144528
A proper understanding of P-gp mediated transport (functionality) at the blood-brain barrier (BBB) and beyond is needed to interpret, understand and predict pharmacokinetic (PK)- pharmacodynamic (PD) relationships of CNS drugs...
2.
Clinckers R, Smolders I, Michotte Y, Ebinger G, Danhof M, Voskuyl R, et al.
Br J Pharmacol
. 2008 Oct;
155(7):1127-38.
PMID: 18836479
Background And Purpose: Accurate prediction of biophase pharmacokinetics (PK) is essential to optimize pharmacotherapy in epilepsy. Here, we characterized the PK of the active metabolite of oxcarbazepine, 10,11-dihydro-10-hydroxy-carbamazepine (MHD) in...
3.
van Vliet E, van Schaik R, Edelbroek P, Voskuyl R, Redeker S, Aronica E, et al.
J Pharmacol Exp Ther
. 2007 Mar;
322(1):141-7.
PMID: 17392402
Recent studies have suggested that overexpression of the multidrug transporter P-glycoprotein (P-gp) in the hippocampal region leads to decreased levels of antiepileptic drugs and contributes to pharmacoresistance that occurs in...
4.
Leaf A, Kang J, Xiao Y, Billman G, Voskuyl R
J Nutr Biochem
. 2004 Nov;
10(8):440-8.
PMID: 15539321
It has been shown that in animals, and probably in humans, n-3 polyunsaturated fatty acids (PUFAs) are antiarrhythmic. We discuss our recent studies on the antiarrhythmic actions of PUFAs. PUFAs...
5.
Jonker D, van de Mheen C, Eilers P, Kruk M, Voskuyl R, Danhof M
Behav Neurosci
. 2003 Oct;
117(5):1076-85.
PMID: 14570556
Antiepileptic drugs can suppress seizures completely, but they may also modify the appearance of drug-resistant seizures. In this study, the effects of three antiepileptic drugs on a seizure pattern were...
6.
Cleton A, Altorf B, Voskuyl R, Danhof M
Eur J Pharm Sci
. 2000 Dec;
12(2):141-50.
PMID: 11102742
The pharmacodynamics of the gamma-aminobutyric acid (GABA) uptake inhibitor (R)-N-(4,4-di-(methylthien-2-yl)but-3-enyl) nipecotic acid (tiagabine) was quantified in rats following chronic (14 days) administration by an integrated pharmacokinetic-pharmacodynamic (PK/PD) modelling approach. The...
7.
Cleton A, Altorf B, Voskuyl R, Danhof M
Br J Pharmacol
. 2000 Jul;
130(5):1037-44.
PMID: 10882388
1. The objective of this investigation was to determine the influence of amygdala kindling on the pharmacodynamics of tiagabine in vivo, using quantitative EEG parameters and extracellular GABA concentrations as...
8.
Della Paschoa O, Hoogerkamp A, Edelbroek P, Voskuyl R, Danhof M
Epilepsy Res
. 2000 Apr;
40(1):41-52.
PMID: 10771257
The purpose of this study was to assess the concentration-anti-convulsant effect relationships of a number of anti-convulsant drugs in the direct cortical stimulation model, to obtain more insight in the...
9.
Cleton A, de Greef H, Edelbroek P, Voskuyl R, Danhof M
J Pharmacokinet Biopharm
. 2000 Mar;
27(3):301-23.
PMID: 10728492
Pharmacological inhibition of GABA uptake transporters provides a mechanism for increasing GABAergic transmission, which may be useful in the treatment of various neurological disorders. The purpose of our investigations was...
10.
Cleton A, de Greef H, Edelbroek P, Voskuyl R, Danhof M
Br J Pharmacol
. 1999 Dec;
128(8):1651-8.
PMID: 10588919
1. The 'effect compartment' model was applied to characterize the pharmacodynamics of the R- and S-isomers of tiagabine in conscious rats in vivo using increase in the beta activity of...