P M Edelbroek
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Explore the profile of P M Edelbroek including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
306
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Recent Articles
1.
Vu D, Alffenaar J, Edelbroek P, Brouwers J, Uges D
Curr Pharm Des
. 2011 Aug;
17(27):2931-9.
PMID: 21834763
Tuberculosis (TB) is a high-burden infectious disease, especially in low and middle-income countries. The efforts to eliminate this disease are challenged by the emergence of multidrug resistance and TB-HIV coinfection....
2.
Vermeij T, Edelbroek P
J Chromatogr B Analyt Technol Biomed Life Sci
. 2007 Jul;
857(1):40-6.
PMID: 17627908
A rapid, simple and robust method is presented for the simultaneous determination of seven antiepileptic drugs (AEDs), including primidone, phenobarbital, phenytoin, carbamazepine with its two major metabolites carbamazepine-10,11-epoxide and carbamazepine-10,11-(trans)-dihydrodiol...
3.
van Vliet E, van Schaik R, Edelbroek P, Voskuyl R, Redeker S, Aronica E, et al.
J Pharmacol Exp Ther
. 2007 Mar;
322(1):141-7.
PMID: 17392402
Recent studies have suggested that overexpression of the multidrug transporter P-glycoprotein (P-gp) in the hippocampal region leads to decreased levels of antiepileptic drugs and contributes to pharmacoresistance that occurs in...
4.
Vermeij T, Edelbroek P
J Chromatogr B Analyt Technol Biomed Life Sci
. 2004 Sep;
810(2):297-303.
PMID: 15380728
A rapid, simple and robust method is presented for the simultaneous determination of the gamma-amino-n-butyric acid (GABA) derivatives pregabalin (PGB), gabapentin (GBP) and vigabatrin (VGB) in human serum by high-performance...
5.
Knoester P, Jonker D, van der Hoeven R, Vermeij T, Edelbroek P, Brekelmans G, et al.
Br J Clin Pharmacol
. 2002 May;
53(5):501-7.
PMID: 11994056
Aims: To investigate the pharmacokinetic and pharmacodynamic profile of midazolam administered as a concentrated intranasal spray, compared with intravenous midazolam, in healthy adult subjects. Methods: Subjects were administered single doses...
6.
Edelbroek P, Augustijn P, De Haan G, Rademaker M, Geesink H
J Neurol Neurosurg Psychiatry
. 2001 Nov;
71(5):708-9.
PMID: 11688497
No abstract available.
7.
Hardus P, Verduin W, Engelsman M, Edelbroek P, Segers J, Berendschot T, et al.
Epilepsia
. 2001 Mar;
42(2):262-7.
PMID: 11240600
Purpose: To describe the correlation between visual field loss and the duration, dosage, and total amount of vigabatrin (VGB) medication in a group of patients with epilepsy. Co-medication of antiepileptic...
8.
Della Paschoa O, Hoogerkamp A, Edelbroek P, Voskuyl R, Danhof M
Epilepsy Res
. 2000 Apr;
40(1):41-52.
PMID: 10771257
The purpose of this study was to assess the concentration-anti-convulsant effect relationships of a number of anti-convulsant drugs in the direct cortical stimulation model, to obtain more insight in the...
9.
Cleton A, de Greef H, Edelbroek P, Voskuyl R, Danhof M
J Pharmacokinet Biopharm
. 2000 Mar;
27(3):301-23.
PMID: 10728492
Pharmacological inhibition of GABA uptake transporters provides a mechanism for increasing GABAergic transmission, which may be useful in the treatment of various neurological disorders. The purpose of our investigations was...
10.
Cleton A, de Greef H, Edelbroek P, Voskuyl R, Danhof M
Br J Pharmacol
. 1999 Dec;
128(8):1651-8.
PMID: 10588919
1. The 'effect compartment' model was applied to characterize the pharmacodynamics of the R- and S-isomers of tiagabine in conscious rats in vivo using increase in the beta activity of...