Qi-En Wang
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Explore the profile of Qi-En Wang including associated specialties, affiliations and a list of published articles.
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85
Citations
2599
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Recent Articles
1.
Qiu Z, Sigh D, Liu Y, Prasad C, Bean N, Yan C, et al.
Theranostics
. 2024 Dec;
14(19):7450-7469.
PMID: 39659585
High-grade serous ovarian cancer (HGSOC), the most lethal epithelial ovarian cancer subtype, faces persistent challenges despite advances in the therapeutic use of PARP inhibitors. Thus, innovative strategies are urgently needed...
2.
Zhang X, Huang Y, Yang Y, Wang Q, Li L
Genome Res
. 2024 Nov;
34(12):2147-2162.
PMID: 39572229
Single-cell lineage tracing (scLT) has emerged as a powerful tool, providing unparalleled resolution to investigate cellular dynamics, fate determination, and the underlying molecular mechanisms. This review thoroughly examines the latest...
3.
Daneshdoust D, He K, Wang Q, Li J, Liu X
Cell Insight
. 2024 Oct;
3(6):100201.
PMID: 39391007
Preclinical models serve as indispensable tools in translational medicine. Specifically, patient-derived models such as patient-derived xenografts (PDX), induced pluripotent stem cells (iPSC), organoids, and recently developed technique of conditional reprogramming...
4.
Lavudi K, Nuguri S, Pandey P, Kokkanti R, Wang Q
Life Sci
. 2024 Sep;
356:123033.
PMID: 39222837
Human ALDH comprise 19 subfamilies in which ALDH1A1, ALDH1A3, ALDH3A1, ALDH5A1, ALDH7A1, and ALDH18A1 are implicated in CSC. Studies have shown that ALDH can also be involved in drug resistance...
5.
Singh D, Qiu Z, Jonathan S, Fa P, Thomas H, Prasad C, et al.
Cancer Lett
. 2024 Jul;
598:217110.
PMID: 38986733
PP2A B55α, encoded by PPP2R2A, acts as a regulatory subunit of the serine/threonine phosphatase PP2A. Despite a frequent loss of heterozygosity of PPP2R2A in cases of non-small cell lung cancer...
6.
Dorayappan K, Wagner V, Park D, Newcomer M, Lightfoot M, Kalaiyarasan D, et al.
J Extracell Biol
. 2024 Jun;
3(2):e92.
PMID: 38939897
The interferon stimulated gene 15 (ISG15), a ubiquitin like protein and its conjugates have been implicated in various human malignancies. However, its role in ovarian cancer progression and metastasis is...
7.
Prasad C, Oo A, Liu Y, Qiu Z, Zhong Y, Li N, et al.
Nat Commun
. 2024 May;
15(1):4667.
PMID: 38821952
Checkpoint kinase 1 (CHK1) is critical for cell survival under replication stress (RS). CHK1 inhibitors (CHK1i's) in combination with chemotherapy have shown promising results in preclinical studies but have displayed...
8.
Rasouli S, Dakic A, Wang Q, Mitchell D, Blakaj D, Putluri N, et al.
J Med Virol
. 2024 May;
96(5):e29665.
PMID: 38738582
The cause of cancer is attributed to the uncontrolled growth and proliferation of cells resulting from genetic changes and alterations in cell behavior, a phenomenon known as epigenetics. Telomeres, protective...
9.
Lavudi K, Banerjee A, Li N, Yang Y, Cai S, Bai X, et al.
NPJ Precis Oncol
. 2023 Jul;
7(1):66.
PMID: 37429899
Poly (ADP-ribose) Polymerase (PARP) inhibitors (PARPi) have been approved for both frontline and recurrent setting in ovarian cancer with homologous recombination (HR) repair deficiency. However, more than 40% of BRCA1/2-mutated...
10.
Prasad C, Oo A, Qiu Z, Li N, Singh D, Xin X, et al.
Res Sq
. 2023 May;
PMID: 37205570
Checkpoint kinase 1 (CHK1) is critical for cell survival under replication stress (RS). CHK1 inhibitors (CHK1i's) in combination with chemotherapy have shown promising results in preclinical studies but minimal efficacy...