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Pushya Krishna

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Articles 4
Citations 99
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Recent Articles
1.
Buyukyoruk M, Krishna P, Santiago-Frangos A, Wiedenheft B
CRISPR J . 2025 Jan; PMID: 39792480
Bacteria and archaea acquire resistance to genetic parasites by preferentially integrating short fragments of foreign DNA at one end of a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR). "Leader" DNA...
2.
Santiago-Frangos A, Nemudryi A, Nemudraia A, Wiegand T, Nichols J, Krishna P, et al.
Methods . 2022 Jun; 205:1-10. PMID: 35690249
Polymerase Chain Reaction (PCR) is the reigning gold standard for molecular diagnostics. However, the SARS-CoV-2 pandemic reveals an urgent need for new diagnostics that provide users with immediate results without...
3.
Santiago-Frangos A, Buyukyoruk M, Wiegand T, Krishna P, Wiedenheft B
Curr Biol . 2021 Jun; 31(16):3515-3524.e6. PMID: 34174210
CRISPR-associated proteins (Cas1 and Cas2) integrate foreign DNA at the "leader" end of CRISPR loci. Several CRISPR leader sequences are reported to contain a binding site for a DNA-bending protein...
4.
Santiago-Frangos A, Hall L, Nemudraia A, Nemudryi A, Krishna P, Wiegand T, et al.
Cell Rep Med . 2021 Jun; 2(6):100319. PMID: 34075364
There is an urgent need for inexpensive new technologies that enable fast, reliable, and scalable detection of viruses. Here, we repurpose the type III CRISPR-Cas system for sensitive and sequence-specific...
5.
McLoughlin M, Orlicky D, Prigge J, Krishna P, Talago E, Cavigli I, et al.
Proc Natl Acad Sci U S A . 2019 May; 116(23):11408-11417. PMID: 31097586
Thioredoxin reductase-1 (TrxR1)-, glutathione reductase (Gsr)-, and Nrf2 transcription factor-driven antioxidant systems form an integrated network that combats potentially carcinogenic oxidative damage yet also protects cancer cells from oxidative death....