Purnima Bhanot
Overview
Explore the profile of Purnima Bhanot including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
516
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0
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Recent Articles
1.
Gilleran J, Ashraf K, Delvillar M, Eck T, Fondekar R, Miller E, et al.
J Med Chem
. 2024 Jul;
67(14):12459.
PMID: 38984428
No abstract available.
2.
Gilleran J, Ashraf K, Delvillar M, Eck T, Fondekar R, Miller E, et al.
J Med Chem
. 2024 Feb;
67(5):3467-3503.
PMID: 38372781
Controlling malaria requires new drugs against . The cGMP-dependent protein kinase (PfPKG) is a validated target whose inhibitors could block multiple steps of the parasite's life cycle. We defined the...
3.
Imhoff R, Rosenthal M, Ashraf K, Bhanot P, Ng C, Flaherty D
Bioorg Med Chem Lett
. 2023 Aug;
94:129458.
PMID: 37634761
Malaria continues to be a major burden on global health, responsible for 619,000 deaths in 2021. The causative agent of malaria is the eukaryotic parasite Plasmodium. Resistance to artemisinin-based combination...
4.
Eck T, De Souza M, Delvillar M, Ashraf K, Bheemanaboina R, Chakrasali R, et al.
Chembiochem
. 2022 Jan;
23(7):e202100704.
PMID: 35044710
Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) is an enticing antimalarial drug target. Novel chemotypes are needed because existing inhibitors have safety issues that may prevent further development. This work demonstrates...
5.
Bheemanaboina R, De Souza M, Lozano Gonzalez M, Mahmood S, Eck T, Kreiss T, et al.
ACS Med Chem Lett
. 2021 Dec;
12(12):1962-1967.
PMID: 34917261
The discovery of new targets for the treatment of malaria, in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors...
6.
Rotella D, Siekierka J, Bhanot P
Front Microbiol
. 2021 Feb;
11:610408.
PMID: 33613463
The primary effector of cGMP signaling in is the cGMP-dependent protein kinase (PKG). Work in human-infective and rodent-infective has provided biological validation of PKG (PfPKG) as a drug target for...
7.
Govindasamy K, Bhanot P
PLoS Pathog
. 2020 Sep;
16(8):e1008131.
PMID: 32866196
Invasion of hepatocytes by Plasmodium sporozoites initiates the pre-erythrocytic step of a malaria infection. Subsequent development of the parasite within hepatocytes and exit from them is essential for starting the...
8.
Shi X, Hai L, Govindasamy K, Gao J, Coppens I, Hu J, et al.
Mol Microbiol
. 2020 May;
114(3):454-467.
PMID: 32432369
Reticulon and REEP family of proteins stabilize the high curvature of endoplasmic reticulum (ER) tubules. Plasmodium berghei Yop1 (PbYop1) is a REEP5 homolog in Plasmodium. Here, we characterize its function...
9.
Parveen N, Bhanot P
Pathogens
. 2019 Aug;
8(3).
PMID: 31370180
The incidence and geographic distribution of human babesiosis is growing in the U.S. Its major causative agent is the protozoan parasite, . is transmitted to humans primarily through the bite...
10.
Djokic V, Akoolo L, Primus S, Schlachter S, Kelly K, Bhanot P, et al.
Front Microbiol
. 2019 Jul;
10:1596.
PMID: 31354683
Lyme disease is the most prominent tick-borne disease in the United States. Co-infections with the tick-transmitted pathogens and sensu stricto are becoming a serious health problem. is an extracellular spirochete...