Punit P Seth
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Explore the profile of Punit P Seth including associated specialties, affiliations and a list of published articles.
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109
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3064
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Recent Articles
21.
Hyjek-Skladanowska M, Vickers T, Napiorkowska A, Anderson B, Tanowitz M, Crooke S, et al.
J Am Chem Soc
. 2020 Mar;
142(16):7456-7468.
PMID: 32202774
The phosphorothioate backbone modification (PS) is one of the most widely used chemical modifications for enhancing the drug-like properties of nucleic acid-based drugs, including antisense oligonucleotides (ASOs). PS-modified nucleic acid...
22.
Chappell A, Gaus H, Berdeja A, Gupta R, Jo M, Prakash T, et al.
Nucleic Acids Res
. 2020 Mar;
48(8):4382-4395.
PMID: 32182359
Conjugation of antisense oligonucleotide (ASO) with a variety of distinct lipophilic moieties like fatty acids and cholesterol increases ASO accumulation and activity in multiple tissues. While lipid conjugation increases tissue...
23.
Ostergaard M, De Hoyos C, Wan W, Shen W, Low A, Berdeja A, et al.
Nucleic Acids Res
. 2020 Jan;
48(4):1691-1700.
PMID: 31980820
Therapeutic oligonucleotides are often modified using the phosphorothioate (PS) backbone modification which enhances stability from nuclease mediated degradation. However, substituting oxygen in the phosphodiester backbone with sulfur introduce chirality into...
24.
Yoshida S, Duong C, Oestergaard M, Fazio M, Chen C, Peralta R, et al.
Nanomedicine
. 2019 Nov;
24:102127.
PMID: 31783139
Neuroblastoma (NB) is the most common extracranial solid tumor in children. The outcomes for aggressive forms of NB remain poor. The aim of this study was to develop a new...
25.
Salinas J, Seth P, Hanessian S
Nucleosides Nucleotides Nucleic Acids
. 2019 Aug;
39(1-3):384-406.
PMID: 31380707
We report the synthesis and biophysical evaluation of an azabicycle dinucleotide with restricted γ, β, and ε torsion angles, featuring the introduction of a piperidine ring that locks the conformation...
26.
Prakash T, Mullick A, Lee R, Yu J, Yeh S, Low A, et al.
Nucleic Acids Res
. 2019 May;
47(12):6029-6044.
PMID: 31127296
Enhancing the functional uptake of antisense oligonucleotide (ASO) in the muscle will be beneficial for developing ASO therapeutics targeting genes expressed in the muscle. We hypothesized that improving albumin binding...
27.
Ostergaard M, Jackson M, Low A, Chappell A, Lee R, Peralta R, et al.
Nucleic Acids Res
. 2019 May;
47(12):6045-6058.
PMID: 31076766
We determined the effect of attaching palmitate, tocopherol or cholesterol to PS ASOs and their effects on plasma protein binding and on enhancing ASO potency in the muscle of rodents...
28.
Shen W, De Hoyos C, Migawa M, Vickers T, Sun H, Low A, et al.
Nat Biotechnol
. 2019 May;
37(6):640-650.
PMID: 31036929
The molecular mechanisms of toxicity of chemically modified phosphorothioate antisense oligonucleotides (PS-ASOs) are not fully understood. Here, we report that toxic gapmer PS-ASOs containing modifications such as constrained ethyl (cEt),...
29.
Migawa M, Shen W, Wan W, Vasquez G, Oestergaard M, Low A, et al.
Nucleic Acids Res
. 2019 Apr;
47(11):5465-5479.
PMID: 31034558
Phosphorothioate-modified antisense oligonucleotides (PS-ASOs) interact with a host of plasma, cell-surface and intracellular proteins which govern their therapeutic properties. Given the importance of PS backbone for interaction with proteins, we...
30.
Seth P, Tanowitz M, Bennett C
J Clin Invest
. 2019 Jan;
129(3):915-925.
PMID: 30688661
Antisense oligonucleotides (ASOs) are chemically synthesized nucleic acid analogs designed to bind to RNA by Watson-Crick base pairing. Following binding to the targeted RNA, the ASO perturbs RNA function by...