Pratibha C Koneru
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Explore the profile of Pratibha C Koneru including associated specialties, affiliations and a list of published articles.
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13
Citations
228
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Recent Articles
1.
Patacchini E, Madia V, Albano A, Ruggieri G, Messore A, Ialongo D, et al.
ACS Med Chem Lett
. 2024 Sep;
15(9):1533-1540.
PMID: 39291012
The HIV-1 integrase (IN) plays a critical role in the viral lifecycle by integrating the viral DNA into the host chromosome. The catalytic function of IN has been exploited as...
2.
Fotsch C, Basu D, Case R, Chen Q, Koneru P, Lo M, et al.
SLAS Discov
. 2024 May;
29(4):100159.
PMID: 38723666
To confirm target engagement of hits from our high-throughput screening efforts, we ran biophysical assays on several hundreds of hits from 15 different high-throughput screening campaigns. Analyzing the biophysical assay...
3.
Adu-Ampratwum D, Pan Y, Koneru P, Antwi J, Hoyte A, Kessl J, et al.
ACS Omega
. 2022 Feb;
7(5):4482-4491.
PMID: 35155940
Human immunodeficiency virus-1 (HIV-1) is the causative agent of acquired immunodeficiency syndrome (AIDS). HIV-1, like all retroviruses, stably integrates its vDNA copy into host chromatin, a process allowing for permanent...
4.
HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio
Liu S, Koneru P, Li W, Pathirage C, Engelman A, Kvaratskhelia M, et al.
Retrovirology
. 2021 Nov;
18(1):37.
PMID: 34809662
Background: During HIV-1 maturation, Gag and Gag-Pol polyproteins are proteolytically cleaved and the capsid protein polymerizes to form the honeycomb capsid lattice. HIV-1 integrase (IN) binds the viral genomic RNA...
5.
Maehigashi T, Ahn S, Kim U, Lindenberger J, Oo A, Koneru P, et al.
PLoS Pathog
. 2021 Jul;
17(7):e1009671.
PMID: 34293041
Allosteric integrase inhibitors (ALLINIs) are a class of experimental anti-HIV agents that target the noncatalytic sites of the viral integrase (IN) and interfere with the IN-viral RNA interaction during viral...
6.
Elliott J, Eschbach J, Koneru P, Li W, Puray-Chavez M, Townsend D, et al.
Elife
. 2020 Sep;
9.
PMID: 32960169
A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations, referred to as class II substitutions, exhibit pleiotropic effects during virus replication. However, the underlying mechanism for the...
7.
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
Koneru P, Francis A, Deng N, Rebensburg S, Hoyte A, Lindenberger J, et al.
Elife
. 2019 May;
8.
PMID: 31120420
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based...
8.
Wilson T, Koneru P, Rebensburg S, Lindenberger J, Kobe M, Cockroft N, et al.
ACS Med Chem Lett
. 2019 Feb;
10(2):215-220.
PMID: 30783506
Allosteric HIV-1 integrase inhibitors (ALLINIs) are a new class of potential antiretroviral therapies with a unique mechanism of action and drug resistance profile. To further extend this class of inhibitors...
9.
Lu W, Tirumuru N, St Gelais C, Koneru P, Liu C, Kvaratskhelia M, et al.
J Biol Chem
. 2018 Jul;
293(34):12992-13005.
PMID: 29976753
The internal -methyladenosine (mA) modification of cellular mRNA regulates post-transcriptional gene expression. The YTH domain family proteins (YTHDF1-3 or Y1-3) bind to mA-modified cellular mRNAs and modulate their metabolism and...
10.
Hoyte A, Jamin A, Koneru P, Kobe M, Larue R, Fuchs J, et al.
J Biol Chem
. 2017 Oct;
292(48):19814-19825.
PMID: 28972144
The pyridine-based multimerization selective HIV-1 integrase (IN) inhibitors (MINIs) are a distinct subclass of allosteric IN inhibitors. MINIs potently inhibit HIV-1 replication during virion maturation by inducing hyper- or aberrant...