James R Fuchs
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Explore the profile of James R Fuchs including associated specialties, affiliations and a list of published articles.
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85
Citations
2374
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Recent Articles
1.
Addo E, Adu-Ampratwum D, Kaweesa E, Agarwal G, Uchenik D, Ninh T, et al.
J Nat Prod
. 2025 Mar;
PMID: 40040236
The tropical plant is known to produce cyclopenta[]benzofuran and other types of rocaglate derivatives including silvestrol () and 5‴-episilvestrol () that are of current pharmacological interest. In the present work,...
2.
Dinh T, Tber Z, Rey J, Mengshetti S, Annamalai A, Haney R, et al.
mBio
. 2024 Oct;
15(11):e0046524.
PMID: 39404354
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are investigational antiretroviral agents that potently impair virion maturation by inducing hyper-multimerization of IN and inhibiting its interaction with viral genomic RNA. The pyrrolopyridine-based...
3.
Oblinger J, Wang J, Wetherell G, Agarwal G, Wilson T, Benson N, et al.
Sci Rep
. 2024 Aug;
14(1):19349.
PMID: 39164287
Inhibition of translation initiation using eIF4A inhibitors like (-)-didesmethylrocaglamide [(-)-DDR] and (-)-rocaglamide [(-)-Roc] is a potential cancer treatment strategy as they simultaneously diminish multiple oncogenic drivers. We showed that human...
4.
Al Subeh Z, Pierre H, Bockbrader R, Tokarski 2nd R, Maldonado A, Haughan M, et al.
Bioorg Med Chem Lett
. 2024 Jul;
110:129875.
PMID: 38964520
Eupenifeldin (1) is a fungal secondary metabolite possessing bis-tropolone moieties that demonstrates nanomolar cytotoxic activity against a number of cancer cell types. As a potential anticancer lead, this meroterpenoid was...
5.
Pierre H, Amrine C, Doyle M, Salvi A, Raja H, Chekan J, et al.
Nat Prod Rep
. 2024 Apr;
41(9):1327-1345.
PMID: 38629495
Covering: 1970 through June of 2023Verticillins are epipolythiodioxopiperazine (ETP) alkaloids, many of which possess potent, nanomolar-level cytotoxicity against a variety of cancer cell lines. Over the last decade, their activity...
6.
Dinh T, Tber Z, Rey J, Mengshetti S, Annamalai A, Haney R, et al.
bioRxiv
. 2024 Feb;
PMID: 38328097
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are investigational antiretroviral agents which potently impair virion maturation by inducing hyper-multimerization of IN and inhibiting its interaction with viral genomic RNA. The pyrrolopyridine-based...
7.
Mukherjee D, Chakraborty S, Bercz L, DAlesio L, Wedig J, Torok M, et al.
iScience
. 2023 Aug;
26(8):107408.
PMID: 37554459
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high metastasis and therapeutic resistance. Activating transcription factor 4 (ATF4), a master regulator of cellular stress, is exploited by cancer cells...
8.
Ayinde O, Sharpe C, Stahl E, Tokarski 2nd R, Lerma J, Muthusamy N, et al.
ACS Med Chem Lett
. 2023 Jul;
14(7):936-942.
PMID: 37465296
Optimization of degrader properties is often a challenge due to their beyond-rule-of-5 nature. Given the paucity of known E3 ligases and the often-limited choice of ligands with varied chemical structures...
9.
Mize B, Salvi A, Ren Y, Burdette J, Fuchs J
Nat Prod Rep
. 2023 Jun;
40(7):1250-1270.
PMID: 37387219
Covering: 2015 through the end of July 2022Ovarian cancer is one of the most common cancers affecting the female reproductive organs and has the highest mortality rate among gynecological cancers....
10.
Chen Z, Ayinde O, Fuchs J, Sun H, Ning X
Commun Chem
. 2023 May;
6(1):102.
PMID: 37253928
Retrosynthesis is a procedure where a target molecule is transformed into potential reactants and thus the synthesis routes can be identified. Recently, computational approaches have been developed to accelerate the...