Pras Pathmanathan
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Explore the profile of Pras Pathmanathan including associated specialties, affiliations and a list of published articles.
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44
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1143
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Recent Articles
21.
Morrison T, Pathmanathan P, Adwan M, Margerrison E
Front Med (Lausanne)
. 2018 Oct;
5:241.
PMID: 30356350
Protecting and promoting public health is the mission of the U.S. Food and Drug Administration (FDA). FDA's Center for Devices and Radiological Health (CDRH), which regulates medical devices marketed in...
22.
Gray R, Pathmanathan P
J Cardiovasc Transl Res
. 2018 Mar;
11(2):80-88.
PMID: 29512059
Patient-specific computer models have been developed representing a variety of aspects of the cardiovascular system spanning the disciplines of electrophysiology, electromechanics, solid mechanics, and fluid dynamics. These physiological mechanistic models...
23.
Pathmanathan P, Gray R
Front Physiol
. 2018 Mar;
9:106.
PMID: 29497385
Computational models of cardiac electrophysiology have a long history in basic science applications and device design and evaluation, but have significant potential for clinical applications in all areas of cardiovascular...
24.
Gray R, Pathmanathan P
PLoS Comput Biol
. 2016 Oct;
12(10):e1005087.
PMID: 27749895
Elucidating the underlying mechanisms of fatal cardiac arrhythmias requires a tight integration of electrophysiological experiments, models, and theory. Existing models of transmembrane action potential (AP) are complex (resulting in over...
25.
Mirams G, Pathmanathan P, Gray R, Challenor P, Clayton R
J Physiol
. 2016 Mar;
594(23):6833-6847.
PMID: 26990229
Key Points: Mathematical and computational models of cardiac physiology have been an integral component of cardiac electrophysiology since its inception, and are collectively known as the Cardiac Physiome. We identify...
26.
Johnstone R, Chang E, Bardenet R, de Boer T, Gavaghan D, Pathmanathan P, et al.
J Mol Cell Cardiol
. 2015 Nov;
96:49-62.
PMID: 26611884
Cardiac electrophysiology models have been developed for over 50years, and now include detailed descriptions of individual ion currents and sub-cellular calcium handling. It is commonly accepted that there are many...
27.
Pathmanathan P, Gray R
Biomed Res Int
. 2015 Nov;
2015:720575.
PMID: 26587544
The mechanisms underlying ventricular fibrillation (VF) are not well understood. The electrical activity on the heart surface during VF has been recorded extensively in the experimental setting and in some...
28.
Pathmanathan P, Shotwell M, Gavaghan D, Cordeiro J, Gray R
Prog Biophys Mol Biol
. 2015 Feb;
117(1):4-18.
PMID: 25661325
Perhaps the most mature area of multi-scale systems biology is the modelling of the heart. Current models are grounded in over fifty years of research in the development of biophysically...
29.
Gurev V, Pathmanathan P, Fattebert J, Wen H, Magerlein J, Gray R, et al.
Biomech Model Mechanobiol
. 2015 Jan;
14(4):829-49.
PMID: 25567753
Modeling of the heart ventricles is one of the most challenging tasks in soft tissue mechanics because cardiac tissue is a strongly anisotropic incompressible material with an active component of...
30.
Carapella V, Bordas R, Pathmanathan P, Lohezic M, Schneider J, Kohl P, et al.
PLoS One
. 2014 Apr;
9(4):e92792.
PMID: 24695115
Tissue microstructure, in particular the alignment of myocytes (fibre direction) and their lateral organisation into sheets, is fundamental to cardiac function. We studied the effect of microstructure on contraction in...