Prakash Parvatkar
Overview
Explore the profile of Prakash Parvatkar including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
35
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Recent Articles
1.
Al-Mohammadi B, Wang J, Jiang H, Parvatkar P, Shkurenko A, Bhatt P, et al.
ACS Appl Mater Interfaces
. 2024 Jan;
PMID: 38230646
The pursuit of developing sensors, characterized by their fluorescence-intensity enhancement or "turn-on" behavior, for accurately detecting noxious small molecules, such as amines, at minimal levels remains a significant challenge. Metal-organic...
2.
Nacheva K, Kulkarni S, Kassu M, Flanigan D, Monastyrskyi A, Iyamu I, et al.
J Med Chem
. 2023 Mar;
66(7):5196-5207.
PMID: 37000900
Kinetic target-guided synthesis (KTGS) is a powerful screening approach that enables identification of small molecule modulators for biomolecules. While many KTGS variants have emerged, a majority of the examples suffer...
3.
Nagaoka Y, Parvatkar P, Hirai G, Ohkanda J
Bioorg Med Chem Lett
. 2021 Jul;
48:128265.
PMID: 34273487
Cdc25B phosphatase catalyzes the dephosphorylation and activation of cyclin-dependent kinases 2 (CDK2/CycA) and their overexpression has been reported in cancers. Although Cdc25B has received much attention as a drug target,...
4.
Alsadun N, Mouchaham G, Guillerm V, Czaban-Jozwiak J, Shkurenko A, Jiang H, et al.
J Am Chem Soc
. 2020 Nov;
142(49):20547-20553.
PMID: 33211955
Herein we report novel mesoporous zirconium-based metal-organic frameworks (MOFs) with zeolitic sodalite () topology. Zr-ZMOF-1 and -2 are constructed based on a novel cantellation design strategy. Distinctly, organic linkers are...
5.
Tsubamoto M, Khanh Le T, Li M, Watanabe T, Matsumi C, Parvatkar P, et al.
Chemistry
. 2019 Aug;
25(59):13531-13536.
PMID: 31393030
Unusual lipid modification of K-Ras makes Ras-directed cancer therapy a challenging task. Aiming to disrupt electrostatic-driven protein-protein interactions (PPIs) of K-Ras with FTase and GGTase I, a series of bivalent...
6.
Smith K, Dowgiallo M, Chiaraviglio L, Parvatkar P, Kim C, Manetsch R, et al.
SLAS Discov
. 2019 Jul;
24(8):842-853.
PMID: 31268804
Carbapenem-resistant Enterobacteriaceae (CRE) are an emerging antimicrobial resistance threat for which few if any therapeutic options remain. Identification of new agents that either inhibit CRE or restore activity of existing...
7.
Ohkanda J, Kusumoto A, Punzalan L, Masuda R, Wang C, Parvatkar P, et al.
Chemistry
. 2018 Sep;
24(60):16066-16071.
PMID: 30238524
Fusicoccins (FCs) exhibit various cellular activities in mammalian cells, but details of the mechanism of action are not fully understood. In this study, we synthesized two pairs of model derivatives...
8.
Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions
Parvatkar P, Kato N, Uesugi M, Sato S, Ohkanda J
J Am Chem Soc
. 2015 Dec;
137(50):15624-7.
PMID: 26632868
Synthetic agents that disrupt intracellular protein-protein interactions (PPIs) are highly desirable for elucidating signaling networks and developing new therapeutics. However, designing cell-penetrating large molecules equipped with the many functional groups...