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» Authors » Prajeeda M Nair

Prajeeda M Nair

Explore the profile of Prajeeda M Nair including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 64
Followers 0
Related Specialties
Hematology
Critical Care
Top 10 Co-Authors
Andrew P Cap
Anand K Ramasubramanian
James A Bynum
Michael A Meledeo
Heather F Pidcoke
Xiaowu Wu
Kristin M Reddoch-Cardenas
John W Weisel
Chaitanya Puligundla
Amit K Saha
Published In
Transfusion
J Trauma Acute Care Surg
Semin Hematol
Br J Haematol
Biomech Model Mechanobiol
Affiliations
Soon will be listed here.
Recent Articles
1.
A novel, quantitative clot retraction assay to evaluate platelet function
Muraoka W, Nair P, Darlington D, Wu X, Bynum J, Cap A
Platelets . 2023 Sep; 34(1):2254403. PMID: 37700390
Blood platelets are crucial to prevent excessive bleeding following injury to blood vessels. Platelets are crucial for the formation of clots and for clot strength. Platelet activation involves aggregation, attachment...
2.
Cold-stored platelets have better preserved contractile function in comparison with room temperature-stored platelets over 21 days
Nair P, Meledeo M, Wells A, Wu X, Bynum J, Leung K, et al.
Transfusion . 2021 Jul; 61 Suppl 1:S68-S79. PMID: 34269433
Although it is well established that transfusion of platelets in cases of severe bleeding reduces mortality, the availability of platelets is hampered by harsh restrictions on shelf life due to...
3.
Cold storage of platelets in platelet additive solution maintains mitochondrial integrity by limiting initiation of apoptosis-mediated pathways
Reddoch-Cardenas K, Peltier G, Chance T, Nair P, Meledeo M, Ramasubramanian A, et al.
Transfusion . 2020 Dec; 61(1):178-190. PMID: 33294977
Background: Cold storage of platelets in plasma maintains hemostatic function and is an attractive alternative to room temperature platelets (RTPs). We have recently shown that functional differences between cold-stored platelets...
4.
Recent advances in use of fresh frozen plasma, cryoprecipitate, immunoglobulins, and clotting factors for transfusion support in patients with hematologic disease
Nair P, Rendo M, Reddoch-Cardenas K, Burris J, Meledeo M, Cap A
Semin Hematol . 2020 Sep; 57(2):73-82. PMID: 32892846
Hematologic diseases include a broad range of acquired and congenital disorders, many of which affect plasma proteins that control hemostasis and immune responses. Therapeutic interventions for these disorders include transfusion...
5.
Image-based analysis and simulation of the effect of platelet storage temperature on clot mechanics under uniaxial strain
Lee S, Nguyen D, Grewal H, Puligundla C, Saha A, Nair P, et al.
Biomech Model Mechanobiol . 2019 Jul; 19(1):173-187. PMID: 31312933
Optimal strength and stability of blood clots are keys to hemostasis and in prevention of hemorrhagic or thrombotic complications. Clots are biocomposite materials composed of fibrin network enmeshing platelets and...
6.
Platelets stored at 4°C contribute to superior clot properties compared to current standard-of-care through fibrin-crosslinking
Nair P, Pandya S, Dallo S, Reddoch K, Montgomery R, Pidcoke H, et al.
Br J Haematol . 2017 Jun; 178(1):119-129. PMID: 28580719
Currently, platelets for transfusion are stored at room temperature (RT) for 5-7 days with gentle agitation, but this is less than optimal because of loss of function and risk of...
7.
Effect of cold storage on shear-induced platelet aggregation and clot strength
Nair P, Pidcoke H, Cap A, Ramasubramanian A
J Trauma Acute Care Surg . 2014 Aug; 77(3 Suppl 2):S88-93. PMID: 25159368
Background: Platelets (PLTs) participate in hemostasis and save lives following trauma. PLTs for transfusion are maintained at room temperature (RT, 22°C), limiting viability to 5 days because of metabolic compromise...