Nobuhiko Tokuriki
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Explore the profile of Nobuhiko Tokuriki including associated specialties, affiliations and a list of published articles.
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57
Citations
3012
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Recent Articles
1.
Erdogan A, Dasmeh P, Socha R, Chen J, Life B, Jun R, et al.
Nat Commun
. 2024 Dec;
15(1):10813.
PMID: 39737968
Heritable phenotypic variation plays a central role in evolution by conferring rapid adaptive capacity to populations. Mechanisms that can explain genetic diversity by describing connections between genotype and organismal fitness...
2.
Saunders J, Damry A, Vongsouthi V, Spence M, Frkic R, Gomez C, et al.
Biochemistry
. 2024 Jun;
63(13):1663-1673.
PMID: 38885634
The mono(2-hydroxyethyl) terephthalate hydrolase (MHETase) from carries out the second step in the enzymatic depolymerization of poly(ethylene terephthalate) (PET) plastic into the monomers terephthalic acid (TPA) and ethylene glycol (EG)....
3.
Frohlich C, Bunzel H, Buda K, Mulholland A, van der Kamp M, Johnsen P, et al.
Nat Catal
. 2024 Jun;
7(5):499-509.
PMID: 38828429
Epistasis, the non-additive effect of mutations, can provide combinatorial improvements to enzyme activity that substantially exceed the gains from individual mutations. Yet the molecular mechanisms of epistasis remain elusive, undermining...
4.
Dasmeh P, Zheng J, Erdogan A, Tokuriki N, Wagner A
Nat Commun
. 2024 Apr;
15(1):3327.
PMID: 38637501
Many organismal traits are genetically determined and covary in evolving populations. The resulting trait correlations can either help or hinder evolvability - the ability to bring forth new and adaptive...
5.
Kehila D, Tokuriki N
Appl Environ Microbiol
. 2024 Feb;
90(2):e0141923.
PMID: 38299817
In this article, we present a method for designing, executing, and analyzing data from a microbial competition experiment. We use fluorescent reporters to label different competing strains and resolve individual...
6.
Buda K, Miton C, Tokuriki N
Nat Commun
. 2023 Dec;
14(1):8508.
PMID: 38129396
Enzyme evolution is characterized by constant alterations of the intramolecular residue networks supporting their functions. The rewiring of these network interactions can give rise to epistasis. As mutations accumulate, the...
7.
Buda K, Miton C, Fan X, Tokuriki N
Trends Biochem Sci
. 2023 Jun;
48(9):751-760.
PMID: 37330341
The plethora of biological functions that sustain life is rooted in the remarkable evolvability of proteins. An emerging view highlights the importance of a protein's initial state in dictating evolutionary...
8.
Sakuma M, Honda S, Ueno H, Tabata K, Miyazaki K, Tokuriki N, et al.
J Am Chem Soc
. 2023 Jan;
145(5):2806-2814.
PMID: 36706363
Enzymes inherently exhibit molecule-to-molecule heterogeneity in their conformational and functional states, which is considered to be a key to the evolution of new functions. Single-molecule enzyme assays enable us to...
9.
Miton C, Tokuriki N
Biochemistry
. 2022 Jul;
62(2):148-157.
PMID: 35830609
Over the years, protein engineers have studied nature and borrowed its tricks to accelerate protein evolution in the test tube. While there have been considerable advances, our ability to generate...
10.
Frohlich C, Sorum V, Tokuriki N, Johnsen P, Samuelsen O
J Antimicrob Chemother
. 2022 Jul;
77(9):2429-2436.
PMID: 35815680
Background: Cefiderocol is a novel siderophore β-lactam with improved hydrolytic stability toward β-lactamases, including carbapenemases, achieved by combining structural moieties of two clinically efficient cephalosporins, ceftazidime and cefepime. Consequently, cefiderocol...