Pouria Dasmeh
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Explore the profile of Pouria Dasmeh including associated specialties, affiliations and a list of published articles.
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29
Citations
181
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Recent Articles
11.
Dasmeh P, Wagner A
J Mol Biol
. 2021 Nov;
434(2):167352.
PMID: 34774567
More than a hundred proteins in yeast reversibly aggregate and phase-separate in response to various stressors, such as nutrient depletion and heat shock. We know little about the protein sequence...
12.
Razban R, Dasmeh P, Serohijos A, Shakhnovich E
Biophys J
. 2021 May;
120(12):2413-2424.
PMID: 33932438
Every amino acid residue can influence a protein's overall stability, making stability highly susceptible to change throughout evolution. We consider the distribution of protein stabilities evolutionarily permittable under two previously...
13.
Keller Valsecchi C, Basilicata M, Georgiev P, Gaub A, Seyfferth J, Kulkarni T, et al.
Nature
. 2020 Nov;
589(7840):137-142.
PMID: 33208948
Confinement of the X chromosome to a territory for dosage compensation is a prime example of how subnuclear compartmentalization is used to regulate transcription at the megabase scale. In Drosophila...
14.
Dasmeh P, Wagner A
Mol Biol Evol
. 2020 Oct;
38(3):940-951.
PMID: 33022038
Protein phase separation can help explain the formation of many nonmembranous organelles. However, we know little about its ability to change in evolution. Here we studied the evolution of the...
15.
Mariani M, Dasmeh P, Fortin A, Caron E, Kalamujic M, Harrison A, et al.
Cells
. 2019 Aug;
8(8).
PMID: 31426476
Interferon (IFN) β and Tumor Necrosis Factor (TNF) are key players in immunity against viruses. Compelling evidence has shown that the antiviral and inflammatory transcriptional response induced by IFNβ is...
16.
Dasmeh P, Serohijos A
Proteins
. 2018 Jul;
86(12):1242-1250.
PMID: 30039542
The extent of nonadditive interaction among mutations or epistasis reflects the ruggedness of the fitness landscape, the mapping of genotype to reproductive fitness. In protein evolution, there is strong support...
17.
Dasmeh P
J Theor Biol
. 2017 Nov;
438:92-95.
PMID: 29162446
In heterogametic organisms, expression of unequal number of X chromosomes in males and females is balanced by a process called dosage compensation. In Drosophila and mammals, dosage compensation involves nearly...
18.
Dasmeh P, Girard E, Serohijos A
Sci Rep
. 2017 Nov;
7(1):15844.
PMID: 29158562
Epistasis or the non-additivity of mutational effects is a major force in protein evolution, but it has not been systematically quantified at the level of a proteome. Here, we estimated...
19.
Dasmeh P, Kepp K
Cell Mol Life Sci
. 2017 Apr;
74(16):3023-3037.
PMID: 28389720
Positive (adaptive) selection has recently been implied in human superoxide dismutase 1 (SOD1), a highly abundant antioxidant protein with energy signaling and antiaging functions, one of very few examples of...
20.
Chlamydas S, Holz H, Samata M, Chelmicki T, Georgiev P, Pelechano V, et al.
Nat Struct Mol Biol
. 2016 May;
23(6):580-9.
PMID: 27183194
Proper gene expression requires coordinated interplay among transcriptional coactivators, transcription factors and the general transcription machinery. We report here that MSL1, a central component of the dosage compensation complex in...