Piotr Raubo
Overview
Explore the profile of Piotr Raubo including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
249
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0
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Recent Articles
1.
Smith J, Barlaam B, Beattie D, Bradshaw L, Chan H, Chiarparin E, et al.
J Med Chem
. 2024 Jul;
67(16):13604-13638.
PMID: 39080842
PRMT5, a type 2 arginine methyltransferase, has a critical role in regulating cell growth and survival in cancer. With the aim of developing MTA-cooperative PRMT5 inhibitors suitable for MTAP-deficient cancers,...
2.
Kettle J, Bagal S, Barratt D, Bodnarchuk M, Boyd S, Braybrooke E, et al.
J Med Chem
. 2023 Jul;
66(13):9147-9160.
PMID: 37395055
The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an Achilles heel that has now rendered this important GTPase druggable. Herein, we report our structure-based...
3.
Finlay M, Anderton M, Bailey A, Boyd S, Brookfield J, Cairnduff C, et al.
J Med Chem
. 2023 Jun;
66(13):9223-9224.
PMID: 37341555
No abstract available.
4.
Kettle J, Bagal S, Bickerton S, Bodnarchuk M, Boyd S, Breed J, et al.
J Med Chem
. 2022 Apr;
65(9):6940-6952.
PMID: 35471939
KRAS is an archetypal high-value intractable oncology drug target. The glycine to cysteine mutation at codon 12 represents an Achilles heel that has now rendered this important GTPase druggable. Herein,...
5.
Raubo P, Carbajo R, McCoull W, Raubo J, Thomas M
Org Biomol Chem
. 2021 Jul;
19(28):6274-6290.
PMID: 34195728
An efficient macrocyclisation approach based on the double aromatic nucleophilic substitution (SNACK) was developed. This methodology allows a facile incorporation of heterocyclic motifs into macrocyclic rings and rapid synthesis of...
6.
Balazs A, Carbajo R, Davies N, Dong Y, Hird A, Johannes J, et al.
J Med Chem
. 2021 Mar;
64(5):2849.
PMID: 33646774
No abstract available.
7.
Jayawant E, Beadle J, Wilkening I, Raubo P, Shipman M, Notman R, et al.
Phys Chem Chem Phys
. 2020 Oct;
22(43):25075-25083.
PMID: 33118559
Peptide-based drugs combine advantages of larger biological therapeutics with those of small molecule drugs, but they generally display poor permeability and metabolic stability. Recently, we introduced a new type of...
8.
Raubo P, Evans R, Willis P
Bioorg Med Chem Lett
. 2020 Jul;
30(18):127412.
PMID: 32717614
The discovery and optimisation of a novel series of potent and selective p38α inhibitors is described. Evaluating the structure-activity relationship of an aminoalkyl substituent at the 3 position of the...
9.
Roesner S, Beadle J, Tam L, Wilkening I, Clarkson G, Raubo P, et al.
Org Biomol Chem
. 2020 Jul;
18(28):5400-5405.
PMID: 32618315
The synthesis and use of oxetane modified dipeptide building blocks in solution and solid-phase peptide synthesis (SPPS) is reported. The preparation of building blocks containing non-glycine residues at the N-terminus...
10.
Balazs A, Carbajo R, Davies N, Dong Y, Hird A, Johannes J, et al.
J Med Chem
. 2019 Jul;
62(21):9418-9437.
PMID: 31361481
The three-dimensional conformations adopted by a free ligand in solution impact bioactivity and physicochemical properties. Solution 1D NMR spectra inherently contain information on ligand conformational flexibility and three-dimensional shape, as...