Paul D Kemmitt
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Explore the profile of Paul D Kemmitt including associated specialties, affiliations and a list of published articles.
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19
Citations
181
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Recent Articles
1.
Smith J, Barlaam B, Beattie D, Bradshaw L, Chan H, Chiarparin E, et al.
J Med Chem
. 2024 Jul;
67(16):13604-13638.
PMID: 39080842
PRMT5, a type 2 arginine methyltransferase, has a critical role in regulating cell growth and survival in cancer. With the aim of developing MTA-cooperative PRMT5 inhibitors suitable for MTAP-deficient cancers,...
2.
Hong F, Aldhous T, Kemmitt P, Bower J
Nat Chem
. 2024 Apr;
16(7):1125-1132.
PMID: 38565976
Homochiral α-amino acids are widely used in pharmaceutical design as key subunits in chiral catalyst synthesis or as building blocks in synthetic biology. Many synthetic methods have been developed to...
3.
Kettle J, Bagal S, Barratt D, Bodnarchuk M, Boyd S, Braybrooke E, et al.
J Med Chem
. 2023 Jul;
66(13):9147-9160.
PMID: 37395055
The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an Achilles heel that has now rendered this important GTPase druggable. Herein, we report our structure-based...
4.
Cooper P, Dalling A, Farrar E, Aldhous T, Grelaud S, Lester E, et al.
Chem Sci
. 2022 Nov;
13(37):11183-11189.
PMID: 36320466
Quaternary benzylic centers are accessed with high atom and step economy by Ir-catalyzed alkene hydroarylation. These studies provide unique examples of the use of non-polarized 1,1-disubstituted alkenes in branch selective...
5.
Tareque R, Hassell-Hart S, Krojer T, Bradley A, Velupillai S, Talon R, et al.
ChemMedChem
. 2020 Aug;
15(24):2513-2520.
PMID: 32812371
Combined photochemical arylation, "nuisance effect" (S Ar) reaction sequences have been employed in the design of small arrays for immediate deployment in medium-throughput X-ray protein-ligand structure determination. Reactions were deliberately...
6.
Britten T, Kemmitt P, Halcovitch N, Coote S
Org Lett
. 2019 Nov;
21(22):9232-9235.
PMID: 31696716
The 4-π-photocyclization of a range of 1,2-dihydropyridazines is described, generating bicyclic 1,2-diazetidines in high yields on multigram scale. The key bicyclic 1,2-diazetidines are versatile synthetic intermediates and were easily converted...
7.
Khan R, Marsh G, Felix R, Kemmitt P, Baud M, Ciulli A, et al.
ACS Omega
. 2019 Aug;
2(8):4328-4332.
PMID: 31457724
, 6-(1-Indol-4-yl)-8-methoxy-1-methyl-4-[1,2,4]triazolo[4,3-][1,4]benzodiazepine-4-acetic acid methyl ester, has been synthesized on a near-gram scale in seven steps with notable improvements in the reported poor-yielding last two steps enabling this key chemical probe...
8.
McCoull W, Cheung T, Anderson E, Barton P, Burgess J, Byth K, et al.
ACS Chem Biol
. 2018 Oct;
13(11):3131-3141.
PMID: 30335946
B-cell lymphoma 6 (BCL6) inhibition is a promising mechanism for treating hematological cancers but high quality chemical probes are necessary to evaluate its therapeutic potential. Here we report potent BCL6...
9.
Khan R, Boonseng S, Kemmitt P, Felix R, Coles S, Tizzard G, et al.
Adv Synth Catal
. 2018 Aug;
359(18):3261-3269.
PMID: 30100832
5-Phenyl-1,3-dihydro--1,4-benzodiazepin-2-ones react under palladium- and visible light photoredox catalysis, in refluxing methanol, with aryldiazonium salts to afford the respective 5-(2-arylphenyl) analogues. With 2- or 4-fluorobenzenediazonium derivatives, both fluoroaryl- and methoxyaryl-...
10.
McCoull W, Abrams R, Anderson E, Blades K, Barton P, Box M, et al.
J Med Chem
. 2017 Jul;
60(14):6459.
PMID: 28714680
No abstract available.