Pingwei Li
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Explore the profile of Pingwei Li including associated specialties, affiliations and a list of published articles.
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Articles
81
Citations
3825
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Recent Articles
11.
Yan Y, Wu L, Yuan Y, Wang H, Yin H, Li M, et al.
PLoS Pathog
. 2023 Sep;
19(9):e1011641.
PMID: 37708231
RNA viruses cause numerous infectious diseases in humans and animals. The crosstalk between RNA viruses and the innate DNA sensing pathways attracts increasing attention. Recent studies showed that the cGAS-STING...
12.
Tang Z, Zhao J, Li Y, Tomer S, Selvaraju M, Tien N, et al.
bioRxiv
. 2023 Jul;
PMID: 37425806
Previously we identified a non-nucleotide tricyclic agonist BDW568 that activates human STING (stimulator of interferon genes) gene variant containing A230 in a human monocyte cell line (THP-1). STING alleles, including...
13.
Lei Y, VanPortfliet J, Chen Y, Bryant J, Li Y, Fails D, et al.
Cell
. 2023 Jun;
186(14):3013-3032.e22.
PMID: 37352855
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic acid sensors remain...
14.
Yang K, Blankenship L, Kuo S, Sheng Y, Li P, Fierke C, et al.
ACS Chem Biol
. 2023 Jan;
18(3):449-455.
PMID: 36629751
As the COVID-19 pathogen, SARS-CoV-2 relies on its main protease (M) for pathogenesis and replication. During crystallographic analyses of M crystals that were exposed to the air, a uniquely Y-shaped,...
15.
Kim I, Dubrow A, Zuniga B, Zhao B, Sherer N, Bastiray A, et al.
Nat Commun
. 2022 Oct;
13(1):5775.
PMID: 36182933
Elucidating how individual mutations affect the protein energy landscape is crucial for understanding how proteins evolve. However, predicting mutational effects remains challenging because of epistasis-the nonadditive interactions between mutations. Here,...
16.
Wei J, Li P, Zhang H, Zhu R
Cell Mol Biol (Noisy-le-grand)
. 2022 Aug;
68(3):158-170.
PMID: 35988176
Tumors are the biggest opponents in the history of human diseases, and they cannot be eliminated so far. The only way to treat tumors is to detect them early so...
17.
Weindel C, Martinez E, Zhao X, Mabry C, Bell S, Vail K, et al.
Cell
. 2022 Jul;
185(17):3214-3231.e23.
PMID: 35907404
Although mutations in mitochondrial-associated genes are linked to inflammation and susceptibility to infection, their mechanistic contributions to immune outcomes remain ill-defined. We discovered that the disease-associated gain-of-function allele Lrrk2 (leucine-rich...
18.
Alugubelli Y, Geng Z, Yang K, Shaabani N, Khatua K, Ma X, et al.
Eur J Med Chem
. 2022 Jul;
240:114596.
PMID: 35839690
Boceprevir is an HCV NSP3 inhibitor that was explored as a repurposed drug for COVID-19. It inhibits the SARS-CoV-2 main protease (M) and contains an α-ketoamide warhead, a P1 β-cyclobutylalanyl...
19.
Ma Y, Yang K, Geng Z, Alugubelli Y, Shaabani N, Vatansever E, et al.
Eur J Med Chem
. 2022 Jul;
240:114570.
PMID: 35779291
As an essential enzyme of SARS-CoV-2, the COVID-19 pathogen, main protease (M) is a viable target to develop antivirals for the treatment of COVID-19. By varying chemical compositions at both...
20.
Jiang M, Shin J, Simeon R, Chang J, Meng R, Wang Y, et al.
PLoS Biol
. 2022 Mar;
20(3):e3001589.
PMID: 35324891
Clostridioides difficile secretes Toxin B (TcdB) as one of its major virulence factors, which binds to intestinal epithelial and subepithelial receptors, including frizzled proteins and chondroitin sulfate proteoglycan 4 (CSPG4)....