Pinar E Coskun
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Explore the profile of Pinar E Coskun including associated specialties, affiliations and a list of published articles.
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11
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1450
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Recent Articles
1.
Flierl A, Schriner S, Hancock S, Coskun P, Wallace D
Free Radic Biol Med
. 2022 Jun;
188:312-327.
PMID: 35714845
Adenine Nucleotide Translocator isoforms (ANTs) exchange ADP/ATP across the inner mitochondrial membrane, are also voltage-activated proton channels and regulate mitophagy and apoptosis. The ANT1 isoform predominates in heart and muscle...
2.
Peiris H, Duffield M, Fadista J, Jessup C, Kashmir V, Genders A, et al.
PLoS Genet
. 2016 May;
12(5):e1006033.
PMID: 27195491
Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to...
3.
Yazdi P, Su H, Ghimbovschi S, Fan W, Coskun P, Nalbandian A, et al.
Clin Transl Sci
. 2013 Oct;
6(5):347-55.
PMID: 24127921
Prader-Willi syndrome (PWS) is a genetic disorder caused by deficiency of imprinted gene expression from the paternal chromosome 15q11-15q13 and clinically characterized by neonatal hypotonia, short stature, cognitive impairment, hypogonadism,...
4.
Coskun P, Busciglio J
Curr Gerontol Geriatr Res
. 2012 May;
2012:383170.
PMID: 22611387
Genome-wide gene deregulation and oxidative stress appear to be critical factors determining the high variability of phenotypes in Down's syndrome (DS). Even though individuals with trisomy 21 exhibit a higher...
5.
Coskun P, Wyrembak J, Derbereva O, Melkonian G, Doran E, Lott I, et al.
J Alzheimers Dis
. 2010 May;
20 Suppl 2:S293-310.
PMID: 20463402
Increasing evidence is implicating mitochondrial dysfunction as a central factor in the etiology of Alzheimer's disease (AD). The most significant risk factor in AD is advanced age and an important...
6.
Su H, Fan W, Coskun P, Vesa J, Gold J, Jiang Y, et al.
Neurosci Lett
. 2009 Jul;
487(2):129-33.
PMID: 19563863
Angelman syndrome (AS) is a severe neurological disorder caused by a deficiency of ubiquitin protein ligase E3A (UBE3A), but the pathophysiology of the disease remains unknown. We now report that...
7.
Subramaniam V, Golik P, Murdock D, Levy S, Kerstann K, Coskun P, et al.
Biochim Biophys Acta
. 2008 Apr;
1777(7-8):666-75.
PMID: 18439414
Genetic inactivation of the nuclear-encoded mitochondrial heart-muscle adenine nucleotide translocator-1 (ANT1), which exports mitochondrial ATP to the cytosol in both humans (ANT1-/-) and mice (Ant1-/-), results in lactic acidosis and...
8.
Fan W, Waymire K, Narula N, Li P, Rocher C, Coskun P, et al.
Science
. 2008 Feb;
319(5865):958-62.
PMID: 18276892
The majority of mitochondrial DNA (mtDNA) mutations that cause human disease are mild to moderately deleterious, yet many random mtDNA mutations would be expected to be severe. To determine the...
9.
Schriner S, Linford N, Martin G, Treuting P, Ogburn C, Emond M, et al.
Science
. 2005 May;
308(5730):1909-11.
PMID: 15879174
To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria (MCAT). Median and...
10.
Coskun P, Beal M, Wallace D
Proc Natl Acad Sci U S A
. 2004 Jul;
101(29):10726-31.
PMID: 15247418
Defects in mitochondrial oxidative phosphorylation have frequently been associated with Alzheimer's disease (AD), and both inherited and somatic mtDNA mutations have been reported in certain AD cases. To determine whether...