Jorge Busciglio
Overview
Explore the profile of Jorge Busciglio including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
38
Citations
1599
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0
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Recent Articles
1.
Flores-Aguilar L, Hamlett E, Araya P, Barone E, Bhattacharyya A, Carmona-Iragui M, et al.
Neuromolecular Med
. 2025 Jan;
27(1):5.
PMID: 39756004
Down syndrome (DS) or trisomy 21 (T21) is present in a significant number of children and adults around the world and is associated with cognitive and medical challenges. Through research,...
2.
Hamlett E, Flores-Aguilar L, Handen B, Potier M, Granholm A, Sherman S, et al.
Mol Syndromol
. 2023 Apr;
14(2):89-100.
PMID: 37064334
Research focused on Down syndrome continued to gain momentum in the last several years and is advancing our understanding of how trisomy 21 (T21) modifies molecular and cellular processes. The...
3.
Aranha M, Iulita M, Montal V, Pegueroles J, Bejanin A, Vaque-Alcazar L, et al.
Alzheimers Dement
. 2023 Apr;
19(11):4817-4827.
PMID: 37021589
Background: Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its...
4.
Vogler E, Mahavongtrakul M, Sarkan K, Bohannan R, Catuara-Solarz S, Busciglio J
Front Neurol
. 2023 Feb;
13:882635.
PMID: 36742045
Vesicular Zn (zinc) is released at synapses and has been demonstrated to modulate neuronal responses. However, mechanisms through which dysregulation of zinc homeostasis may potentiate neuronal dysfunction and neurodegeneration are...
5.
Yeo M, Chen Y, Jiang C, Chen G, Wang K, Chandra S, et al.
Nat Commun
. 2021 Oct;
12(1):6208.
PMID: 34707084
Inhibitory GABA-ergic neurotransmission is fundamental for the adult vertebrate central nervous system and requires low chloride concentration in neurons, maintained by KCC2, a neuroprotective ion transporter that extrudes intracellular neuronal...
6.
Dierssen M, Herault Y, Helguera P, Martinez de Lagran M, Vazquez A, Christian B, et al.
Mol Syndromol
. 2021 Aug;
12(4):202-218.
PMID: 34421499
Research focused on Down syndrome has increased in the last several years to advance understanding of the consequences of trisomy 21 (T21) on molecular and cellular processes and, ultimately, on...
7.
Flores-Aguilar L, Iulita M, Kovecses O, Torres M, Levi S, Zhang Y, et al.
Brain
. 2020 Nov;
143(12):3653-3671.
PMID: 33206953
Epidemiological and experimental studies suggest that a disease-aggravating neuroinflammatory process is present at preclinical stages of Alzheimer's disease. Given that individuals with Down syndrome are at increased genetic risk of...
8.
Hwang S, Williams J, Kneissig M, Lioudyno M, Rivera I, Helguera P, et al.
Cell Rep
. 2019 Nov;
29(8):2473-2488.e5.
PMID: 31747614
An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular...
9.
Reeves R, Delabar J, Potier M, Bhattacharyya A, Head E, Lemere C, et al.
Mol Syndromol
. 2019 Feb;
9(6):279-286.
PMID: 30800043
In the last decade, a number of important research advances in different fields have allowed Down syndrome (DS) research to flourish, creating a time of both unparalleled opportunity and considerable...
10.
Zamponi E, Zamponi N, Coskun P, Quassollo G, Lorenzo A, Cannas S, et al.
Aging Cell
. 2018 Jul;
17(5):e12812.
PMID: 30028071
Mounting evidence implicates chronic oxidative stress as a critical driver of the aging process. Down syndrome (DS) is characterized by a complex phenotype, including early senescence. DS cells display increased...