Heshan Peiris
Overview
Explore the profile of Heshan Peiris including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
546
Followers
0
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Recent Articles
1.
Kang S, Chen E, Cifuentes H, Co J, Cole G, Graham J, et al.
Biofabrication
. 2024 Aug;
16(4).
PMID: 39189069
Recent years have seen the creation and popularization of various complexmodels (CIVMs), such as organoids and organs-on-chip, as a technology with the potential to reduce animal usage in pharma while...
2.
Wattegedera M, Silva D, Sooriyabandara C, Wimaladasa P, Siriwardena R, Piyasena M, et al.
Animals (Basel)
. 2022 Mar;
12(5).
PMID: 35268228
Visual leopard identifications performed with camera traps using the capture-recapture method only consider areas of the skin that are visible to the equipment. The method presented here considered the spot...
3.
Bevacqua R, Lam J, Peiris H, Whitener R, Kim S, Gu X, et al.
Genes Dev
. 2021 Jan;
35(3-4):234-249.
PMID: 33446570
The physiological functions of many vital tissues and organs continue to mature after birth, but the genetic mechanisms governing this postnatal maturation remain an unsolved mystery. Human pancreatic β cells...
4.
Kim S, Whitener R, Peiris H, Gu X, Chang C, Lam J, et al.
Development
. 2020 Feb;
147(6).
PMID: 32108026
Reliance on rodents for understanding pancreatic genetics, development and islet function could limit progress in developing interventions for human diseases such as diabetes mellitus. Similarities of pancreas morphology and function...
5.
Rotter D, Peiris H, Grinsfelder D, Martin A, Burchfield J, Parra V, et al.
EMBO Rep
. 2018 Nov;
19(12).
PMID: 30389725
Increasing non-shivering thermogenesis (NST), which expends calories as heat rather than storing them as fat, is championed as an effective way to combat obesity and metabolic disease. Innate mechanisms constraining...
6.
Peiris H, Park S, Louis S, Gu X, Lam J, Asplund O, et al.
Nat Commun
. 2018 Sep;
9(1):3855.
PMID: 30242153
Developing systems to identify the cell type-specific functions regulated by genes linked to type 2 diabetes (T2D) risk could transform our understanding of the genetic basis of this disease. However,...
7.
Peiris H, Keating D
Clin Exp Pharmacol Physiol
. 2017 Nov;
45(4):377-383.
PMID: 29094385
The regulator of calcineurin 1 (RCAN1) was first discovered as a gene located on human chromosome 21, expressed in neurons and overexpressed in the brains of Down syndrome individuals. Increased...
8.
Pierini A, Iliopoulou B, Peiris H, Perez-Cruz M, Baker J, Hsu K, et al.
JCI Insight
. 2017 Oct;
2(20).
PMID: 29046484
Cellular therapies based on permanent genetic modification of conventional T cells have emerged as a promising strategy for cancer. However, it remains unknown if modification of T cell subsets, such...
9.
Rojas-Canales D, Penko D, Myo Min K, Parham K, Peiris H, Haberberger R, et al.
Diabetes
. 2017 Feb;
66(5):1301-1311.
PMID: 28174291
Pancreatic islet transplantation is a promising clinical treatment for type 1 diabetes, but success is limited by extensive β-cell death in the immediate posttransplant period and impaired islet function in...
10.
Banerjee R, Cyphert H, Walker E, Chakravarthy H, Peiris H, Gu X, et al.
Diabetes
. 2016 May;
65(8):2331-41.
PMID: 27217483
β-Cell proliferation and expansion during pregnancy are crucial for maintaining euglycemia in response to increased metabolic demands placed on the mother. Prolactin and placental lactogen signal through the prolactin receptor...