Pieterjan Dierickx
Overview
Explore the profile of Pieterjan Dierickx including associated specialties, affiliations and a list of published articles.
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Recent Articles
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Latimer M, Williams L, Shanmugan G, Carpenter B, Lazar M, Dierickx P, et al.
Commun Biol
. 2023 Nov;
6(1):1149.
PMID: 37952007
Circadian disruption increases cardiovascular disease (CVD) risk, through poorly understood mechanisms. Given that small RNA species are critical modulators of cardiac physiology/pathology, we sought to determine the extent to which...
3.
Mia S, Sonkar R, Williams L, Latimer M, Rawnsley D, Rana S, et al.
JACC Basic Transl Sci
. 2023 Oct;
8(9):1141-1156.
PMID: 37791313
Circadian clocks temporally orchestrate biological processes critical for cellular/organ function. For example, the cardiomyocyte circadian clock modulates cardiac metabolism, signaling, and electrophysiology over the course of the day, such that,...
4.
Dierickx P, Carpenter B, Celwyn I, Kelly D, Baur J, Lazar M
Front Mol Med
. 2023 Jun;
2.
PMID: 37389009
The REV-ERB nuclear receptors are key components of the circadian clock. Loss of REV-ERBs in the mouse heart causes dilated cardiomyopathy and premature lethality. This is associated with a marked...
5.
Yamamoto T, Maurya S, Pruzinsky E, Batmanov K, Xiao Y, Sulon S, et al.
J Clin Invest
. 2023 Mar;
133(9).
PMID: 36927960
During the development of heart failure (HF), the capacity for cardiomyocyte (CM) fatty acid oxidation (FAO) and ATP production is progressively diminished, contributing to pathologic cardiac hypertrophy and contractile dysfunction....
6.
Carpenter B, Dierickx P
Am J Physiol Cell Physiol
. 2022 Sep;
323(4):C1168-C1176.
PMID: 36062878
Nicotinamide adenine dinucleotide (NAD) is a critical redox factor and coenzyme with rhythmic availability, and reduced NAD levels are a common factor in many disease states, including risk factors associated...
7.
Circadian REV-ERBs repress to activate NAMPT-dependent NAD biosynthesis and sustain cardiac function
Dierickx P, Zhu K, Carpenter B, Jiang C, Vermunt M, Xiao Y, et al.
Nat Cardiovasc Res
. 2022 Jan;
1(1):45-58.
PMID: 35036997
The heart is a highly metabolic organ that uses multiple energy sources to meet its demand for ATP production. Diurnal feeding-fasting cycles result in substrate availability fluctuations which, together with...
8.
Chirico N, van Laake L, Sluijter J, van Mil A, Dierickx P
Curr Opin Pharmacol
. 2020 Dec;
57:49-59.
PMID: 33338891
The circadian clock synchronizes the body into 24-h cycles, thereby anticipating variations in tissue-specific diurnal tasks, such as response to increased cardiac metabolic demand during the active period of the...
9.
Dhillon P, Park J, Hurtado Del Pozo C, Li L, Doke T, Huang S, et al.
Cell Metab
. 2020 Dec;
33(2):379-394.e8.
PMID: 33301705
Kidney disease is poorly understood because of the organ's cellular diversity. We used single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular composition but also in...
10.
Guan D, Xiong Y, Trinh T, Xiao Y, Hu W, Jiang C, et al.
Science
. 2020 Aug;
369(6509):1388-1394.
PMID: 32732282
Most cells of the body contain molecular clocks, but the requirement of peripheral clocks for rhythmicity and their effects on physiology are not well understood. We show that deletion of...