Pieter J de Jong
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Explore the profile of Pieter J de Jong including associated specialties, affiliations and a list of published articles.
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100
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14490
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Recent Articles
11.
West D, Engelhard E, Adkisson M, Nava A, Kirov J, Cipollone A, et al.
PLoS Genet
. 2016 Feb;
12(2):e1005691.
PMID: 26839965
The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the frequency and characteristics of off-target effects....
12.
West D, Pasumarthi R, Baridon B, Djan E, Trainor A, Griffey S, et al.
Genome Res
. 2015 Jan;
25(4):598-607.
PMID: 25591789
Expression of the bacterial beta-galactosidase reporter gene (lacZ) in the vector used for the Knockout Mouse Project (KOMP) is driven by the endogenous promoter of the target gene. In tissues...
13.
Degagne E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, et al.
J Clin Invest
. 2014 Oct;
124(12):5368-84.
PMID: 25347472
Growing evidence supports a link between inflammation and cancer; however, mediators of the transition between inflammation and carcinogenesis remain incompletely understood. Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades the bioactive sphingolipid...
14.
Carbone L, Harris R, Gnerre S, Veeramah K, Lorente-Galdos B, Huddleston J, et al.
Nature
. 2014 Sep;
513(7517):195-201.
PMID: 25209798
Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes....
15.
Lee J, Tu Y, Tatar A, Wu D, Nobumori C, Jung H, et al.
Mol Biol Cell
. 2014 Mar;
25(10):1666-75.
PMID: 24672053
Lamins B1 and B2 (B-type lamins) have very similar sequences and are expressed ubiquitously. In addition, both Lmnb1- and Lmnb2-deficient mice die soon after birth with neuronal layering abnormalities in...
16.
Zimin A, Stevens K, Crepeau M, Holtz-Morris A, Koriabine M, Marcais G, et al.
Genetics
. 2014 Mar;
196(3):875-90.
PMID: 24653210
Conifers are the predominant gymnosperm. The size and complexity of their genomes has presented formidable technical challenges for whole-genome shotgun sequencing and assembly. We employed novel strategies that allowed us...
17.
Heidersbach A, Saxby C, Carver-Moore K, Huang Y, Ang Y, de Jong P, et al.
Elife
. 2013 Nov;
2:e01323.
PMID: 24252873
microRNA-1 (miR-1) is an evolutionarily conserved, striated muscle-enriched miRNA. Most mammalian genomes contain two copies of miR-1, and in mice, deletion of a single locus, miR-1-2, causes incompletely penetrant lethality...
18.
Jung H, Nobumori C, Goulbourne C, Tu Y, Lee J, Tatar A, et al.
Proc Natl Acad Sci U S A
. 2013 May;
110(21):E1923-32.
PMID: 23650370
The role of protein farnesylation in lamin A biogenesis and the pathogenesis of progeria has been studied in considerable detail, but the importance of farnesylation for the B-type lamins, lamin...
19.
Howe K, Clark M, Torroja C, Torrance J, Berthelot C, Muffato M, et al.
Nature
. 2013 Apr;
496(7446):498-503.
PMID: 23594743
Zebrafish have become a popular organism for the study of vertebrate gene function. The virtually transparent embryos of this species, and the ability to accelerate genetic studies by gene knockdown...
20.
Smith J, Kuraku S, Holt C, Sauka-Spengler T, Jiang N, Campbell M, et al.
Nat Genet
. 2013 Feb;
45(4):415-21, 421e1-2.
PMID: 23435085
Lampreys are representatives of an ancient vertebrate lineage that diverged from our own ∼500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) genome...