Pierre-Luc Germain
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Explore the profile of Pierre-Luc Germain including associated specialties, affiliations and a list of published articles.
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1594
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Recent Articles
1.
Gilardi C, Martins H, Levone B, Bianco A, Bicker S, Germain P, et al.
EMBO Rep
. 2025 Mar;
PMID: 40065182
Mood disorders (MDs) are caused by an interplay of genetic and environmental (GxE) risk factors. However, molecular pathways engaged by GxE risk factors are poorly understood. Using small-RNA sequencing in...
2.
Salovska B, Li W, Bernhardt O, Germain P, Gandhi T, Reiter L, et al.
bioRxiv
. 2024 Nov;
PMID: 39554001
Measuring protein turnover is essential for understanding cellular biological processes and advancing drug discovery. The multiplex DIA mass spectrometry (DIA-MS) approach, combined with dynamic SILAC labeling (pulse-SILAC, or pSILAC), has...
3.
Gerbaldo F, Sonder E, Fischer V, Frei S, Wang J, Gapp K, et al.
PLoS Comput Biol
. 2024 Oct;
20(10):e1011971.
PMID: 39441876
ATAC-seq has emerged as a rich epigenome profiling technique, and is commonly used to identify Transcription Factors (TFs) underlying given phenomena. A number of methods can be used to identify...
4.
Luo S, Germain P, Robinson M, von Meyenn F
Genome Biol
. 2024 Aug;
25(1):225.
PMID: 39152456
Background: Single-cell chromatin accessibility assays, such as scATAC-seq, are increasingly employed in individual and joint multi-omic profiling of single cells. As the accumulation of scATAC-seq and multi-omics datasets continue, challenges...
5.
Mihailovich M, Germain P, Shyti R, Pozzi D, Noberini R, Liu Y, et al.
J Clin Invest
. 2024 Jul;
134(14).
PMID: 39007270
Copy number variation (CNV) at 7q11.23 causes Williams-Beuren syndrome (WBS) and 7q microduplication syndrome (7Dup), neurodevelopmental disorders (NDDs) featuring intellectual disability accompanied by symmetrically opposite neurocognitive features. Although significant progress...
6.
Narayanan R, Levone B, Winterer J, Nanda P, Muller A, Lobriglio T, et al.
Cell Rep
. 2024 Jul;
43(7):114429.
PMID: 38968074
Social deficits are frequently observed in patients suffering from neurodevelopmental disorders, but the molecular mechanisms regulating sociability are still poorly understood. We recently reported that the loss of the microRNA...
7.
Robinson M, Cai P, Emons M, Gerber R, Germain P, Gunz S, et al.
PLoS Comput Biol
. 2024 Jun;
20(6):e1012174.
PMID: 38900718
Computational biologists are frequently engaged in collaborative data analysis with wet lab researchers. These interdisciplinary projects, as necessary as they are to the scientific endeavor, can be surprisingly challenging due...
8.
Gerbaldo F, Sonder E, Fischer V, Frei S, Wang J, Gapp K, et al.
bioRxiv
. 2024 Mar;
PMID: 38496482
ATAC-seq has emerged as a rich epigenome profiling technique, and is commonly used to identify Transcription Factors (TFs) underlying given phenomena. A number of methods can be used to identify...
9.
Privitera M, von Ziegler L, Floriou-Servou A, Duss S, Zhang R, Waag R, et al.
Elife
. 2024 Mar;
12.
PMID: 38477670
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here, we...
10.
Gazorpak M, Hugentobler K, Paul D, Germain P, Kretschmer M, Ivanova I, et al.
Nat Commun
. 2023 Dec;
14(1):8177.
PMID: 38071198
Counteracting the overactivation of glucocorticoid receptors (GR) is an important therapeutic goal in stress-related psychiatry and beyond. The only clinically approved GR antagonist lacks selectivity and induces unwanted side effects....