Philipp Kaldis
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Explore the profile of Philipp Kaldis including associated specialties, affiliations and a list of published articles.
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124
Citations
4555
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Recent Articles
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Zhao L, Kaldis P
FEBS J
. 2022 Mar;
290(9):2279-2291.
PMID: 35303396
Mammalian metabolism comprises a series of interlinking pathways that include two major cycles: the folate and methionine cycles. The folate-mediated metabolic cycle uses several oxidation states of tetrahydrofolate to carry...
13.
Sanches J, Zhao L, Salehi A, Wollheim C, Kaldis P
FEBS J
. 2021 Nov;
290(3):620-648.
PMID: 34847289
Diabetes is a complex and multifactorial disease that affects millions of people worldwide, reducing the quality of life significantly, and results in grave consequences for our health care system. In...
14.
Zhao L, Mondal D, Li W, Mu Y, Kaldis P
Proteins
. 2021 Jul;
90(1):123-130.
PMID: 34318530
Lignin is one of the world's most abundant organic polymers, and 2-pyrone-4,6-dicarboxylate lactonase (LigI) catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) in the degradation of lignin. The pH has profound effects...
15.
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential
Zhao L, Bjorklund M, Caldez M, Zheng J, Kaldis P
Oncogene
. 2021 Mar;
40(13):2339-2354.
PMID: 33664451
Most of the drugs currently prescribed for cancer treatment are riddled with substantial side effects. In order to develop more effective and specific strategies to treat cancer, it is of...
16.
Xu J, Kausalya P, Van Hul N, Caldez M, Xu S, Ong A, et al.
Gastroenterology
. 2021 Jan;
160(6):2103-2118.
PMID: 33465371
Background & Aims: Liver tight junctions (TJs) establish tissue barriers that isolate bile from the blood circulation. TJP2/ZO-2-inactivating mutations cause progressive cholestatic liver disease in humans. Because the underlying mechanisms...
17.
Ow J, Caldez M, Zafer G, Foo J, Li H, Ghosh S, et al.
Elife
. 2020 Dec;
9.
PMID: 33345777
Cell cycle progression and lipid metabolism are well-coordinated processes required for proper cell proliferation. In liver diseases that arise from dysregulated lipid metabolism, proliferation is diminished. To study the outcome...
18.
Cyclin-Dependent Kinase 1 Is Essential for Muscle Regeneration and Overload Muscle Fiber Hypertrophy
Kobayashi Y, Tanaka T, Mulati M, Ochi H, Sato S, Kaldis P, et al.
Front Cell Dev Biol
. 2020 Nov;
8:564581.
PMID: 33163487
Satellite cell proliferation is an essential step in proper skeletal muscle development and muscle regeneration. However, the mechanisms regulating satellite cell proliferation are relatively unknown compared to the knowledge associated...
19.
Adon A, Zeng X, Harrison M, Sannem S, Kiyokawa H, Kaldis P, et al.
Mol Cell Biol
. 2020 Nov;
40(23).
PMID: 33159003
No abstract available.
20.
Dewhurst M, Ow J, Zafer G, van Hul N, Wollmann H, Bisteau X, et al.
PLoS Genet
. 2020 Nov;
16(11):e1009084.
PMID: 33147210
The liver possesses a remarkable regenerative capacity based partly on the ability of hepatocytes to re-enter the cell cycle and divide to replace damaged cells. This capability is substantially reduced...