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Philip W Zoltick

Explore the profile of Philip W Zoltick including associated specialties, affiliations and a list of published articles. Areas
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Articles 29
Citations 882
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Recent Articles
11.
Joyeux L, Danzer E, Limberis M, Zoltick P, Radu A, Flake A, et al.
Hum Gene Ther Methods . 2014 Mar; 25(3):197-205. PMID: 24660751
Virus-mediated gene transfer to the fetal lung epithelium holds considerable promise for the therapeutic management of prenatally diagnosed, potentially life-threatening inherited lung diseases. In this study we hypothesized that efficient...
12.
Xu J, Zoltick P, Gamero A, Gallucci S
J Leukoc Biol . 2014 Mar; 96(1):93-103. PMID: 24598055
Mutations in the Trex1 are associated with a spectrum of type I IFN-dependent autoimmune diseases. Trex1 plays an essential role in preventing accumulation of excessive cytoplasmic DNA, avoiding cell-intrinsic innate...
13.
Sriram U, Xu J, Chain R, Varghese L, Chakhtoura M, Bennett H, et al.
PLoS One . 2014 Feb; 9(1):e87668. PMID: 24489947
Th2-inducing pathological conditions such as parasitic diseases increase susceptibility to viral infections through yet unclear mechanisms. We have previously reported that IL-4, a pivotal Th2 cytokine, suppresses the response of...
14.
Wu C, Endo M, Yang B, Radecki M, Davis P, Zoltick P, et al.
Mol Ther . 2012 Oct; 21(1):8-17. PMID: 23089732
Cleft palate is a developmental defect resulting from the failure of embryonic palatal shelves to fuse with each other at a critical time. Immediately before and during palatal fusion (E13-E15...
15.
Stitelman D, Endo M, Bora A, Muvarak N, Zoltick P, Flake A, et al.
Mol Ther . 2010 Jun; 18(9):1615-23. PMID: 20571539
Presently, in vivo methods to efficiently and broadly transduce all major cell types throughout both the central (CNS) and peripheral adult nervous system (PNS) are lacking. In this study, we...
16.
Katz A, Keswani S, Habli M, Lim F, Zoltick P, Midrio P, et al.
Am J Obstet Gynecol . 2009 Sep; 201(5):499.e1-8. PMID: 19716119
Objective: We hypothesized that gene transfer of select growth factors to the placenta may enhance placental and fetal growth. Thus, we examined the effect of 8 growth factor transgenes on...
17.
Merianos D, Tiblad E, Santore M, Todorow C, Laje P, Endo M, et al.
J Clin Invest . 2009 Aug; 119(9):2590-600. PMID: 19652363
The lack of fetal immune responses to foreign antigens, i.e., fetal immunologic tolerance, is the most compelling rationale for prenatal stem cell and gene therapy. However, the frequency of engraftment...
18.
Laje P, Shang D, Cao W, Niiya M, Endo M, Radu A, et al.
Blood . 2009 Jan; 113(10):2172-80. PMID: 19141866
ADAMTS13, a metalloprotease primarily synthesized in liver and endothelial cells, cleaves von Willebrand factor (VWF) at the central A2 domain, thereby reducing the sizes of circulating VWF multimers. Genetic or...
19.
Niiya M, Endo M, Shang D, Zoltick P, Muvarak N, Cao W, et al.
Mol Ther . 2008 Oct; 17(1):34-41. PMID: 18957966
Deficiency of A Disintegrin And Metalloprotease with ThromboSpondin (ADAMTS13) results in thrombotic thrombocytopenic purpura (TTP). Plasma infusion or exchange is the only effective treatment to date. We show in this...
20.
Behrens E, Ning Y, Muvarak N, Zoltick P, Flake A, Gallucci S
J Immunol . 2008 Aug; 181(5):3018-26. PMID: 18713972
A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses TLR-induced TNF-alpha and IL-12 production and inhibits effective Ag presentation. Although the proposed physiologic role...