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Alan W Flake

Explore the profile of Alan W Flake including associated specialties, affiliations and a list of published articles. Areas
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Articles 282
Citations 4016
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Recent Articles
1.
Cohen J, De Bie F, Viaene A, OGrady N, Rentas S, Coons B, et al.
Sci Rep . 2024 Nov; 14(1):28840. PMID: 39572605
Our group has developed an extra-uterine environment for newborn development (EXTEND) using an ovine model, that aims to mimic the womb to improve short and long-term health outcomes associated with...
2.
Peers de Nieuwburgh M, Hunt M, Chandrasekaran P, Vincent T, Hayes K, Randazzo I, et al.
Am J Respir Cell Mol Biol . 2024 Oct; PMID: 39453404
Severe fetal hypoxia poses a significant risk to lung development resulting in severe postnatal complications. Existing chronic hypoxia animal models lack the ability to achieve pathologically reduced fetal oxygen without...
3.
di Natale A, Flohr S, Mathew L, Katterman C, Gallagher C, Reynolds T, et al.
Fetal Diagn Ther . 2024 Sep; :1-13. PMID: 39245038
Introduction: Congenital pulmonary airway malformations (CPAM), intra- and extralobar bronchopulmonary sequestrations (iBPS/eBPS), CPAM-BPS hybrid lesions (HL), congenital lobar emphysema (CLE), bronchial atresia (BA), and foregut duplication cysts (FDC), collectively referred...
4.
Riley J, Berkowitz C, Luks V, Dave A, Cyril-Olutayo M, Pogoriler J, et al.
Blood Adv . 2024 Jun; 8(17):4523-4538. PMID: 38941538
In utero hematopoietic cell transplantation is an experimental nonmyeloablative therapy with potential applications in hematologic disorders, including sickle cell disease (SCD). Its clinical utility has been limited due to the...
5.
Agarwal D, Hunt M, Sridharan A, Larson A, Rychik J, Licht D, et al.
Pediatr Res . 2024 Jun; 97(1):145-152. PMID: 38849480
Background: Children with congenital heart disease (CHD) demonstrate long-term neurodevelopmental impairments. We investigated contrast-enhanced ultrasound (CEUS) cerebral perfusion in a fetal animal model exposed to sub-physiologic oxygen at equivalent levels...
6.
Peers de Nieuwburgh M, Dave A, Khan S, Ngo M, Hayes K, Slipenchuk M, et al.
Pediatr Res . 2024 Jun; 96(7):1616-1625. PMID: 38834782
Background: Our team has previously reported physiologic support by the EXTra-uterine Environment for Neonatal Development (EXTEND) of 105 to 117 days gestational age (GA) lambs for up to 28 days...
7.
Mosquera M, Yuter S, Flake A
Semin Fetal Neonatal Med . 2023 Nov; 28(5):101485. PMID: 38030438
The ex-utero intrapartum treatment (EXIT) procedure was originally developed to reverse tracheal occlusion in fetuses with severe congenital diaphragmatic hernia that underwent fetal tracheal occlusion. The EXIT procedure has since...
8.
Bose S, Stratigis J, Ahn N, Pogoriler J, Hedrick H, Rintoul N, et al.
J Pediatr Surg . 2023 Oct; 58(12):2384-2390. PMID: 37813715
Introduction: Fetuses with large lung lesions including congenital cystic adenomatoid malformations (CCAMs) are at risk for cardiopulmonary compromise. Prenatal maternal betamethasone and cyst drainage for micro- and macrocystic lesions respectively...
9.
de Jong I, Hunt M, Chen D, Du Y, Llewellyn J, Gupta K, et al.
J Hepatol . 2023 Aug; 79(6):1396-1407. PMID: 37611641
Background & Aims: Biliary atresia (BA) is an obstructive cholangiopathy that initially affects the extrahepatic bile ducts (EHBDs) of neonates. The etiology is uncertain, but evidence points to a prenatal...
10.
Feudtner C, De Bie F, Flake A
JAMA Pediatr . 2023 Aug; 177(10):1110-1111. PMID: 37578759
No abstract available.