Philip Lecane
Overview
Explore the profile of Philip Lecane including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
7
Citations
131
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Magda D, Lecane P, Prescott J, Thiemann P, Ma X, Dranchak P, et al.
BMC Genomics
. 2008 Nov;
9:521.
PMID: 18980691
Background: Interactions between the gene products encoded by the mitochondrial and nuclear genomes play critical roles in eukaryotic cellular function. However, the effects mitochondrial DNA (mtDNA) levels have on the...
2.
Magda D, Lecane P, Wang Z, Hu W, Thiemann P, Ma X, et al.
Cancer Res
. 2008 Jul;
68(13):5318-25.
PMID: 18593933
Several water-solubilized versions of the zinc ionophore 1-hydroxypyridine-2-thione (ZnHPT), synthesized as part of the present study, have been found both to increase the intracellular concentrations of free zinc and to...
3.
Naumovski L, Sirisawad M, Lecane P, Chen J, Ramos J, Wang Z, et al.
Mol Cancer Ther
. 2006 Nov;
5(11):2798-805.
PMID: 17121926
Sapphyrins are pentapyrrolic metal-free expanded porphyrins with potential medical use as anticancer agents. The novel sapphyrin derivative, PCI-2050, functionalized with 2-[2-(2-methoxyethoxy)ethoxy]ethoxy groups to enhance solubility and a modified bipyrrole moiety...
4.
Naumovski L, Ramos J, Sirisawad M, Chen J, Thiemann P, Lecane P, et al.
Mol Cancer Ther
. 2005 Jun;
4(6):968-76.
PMID: 15956254
Sapphyrins are pentapyrrolic, metal-free, expanded porphyrins. In the present study, the activity of sapphyrins as anticancer agents in hematopoietic-derived tumor cells was explored. It was found that a dihydroxylated water-soluble...
5.
Magda D, Lecane P, Miller R, Lepp C, Miles D, Mesfin M, et al.
Cancer Res
. 2005 May;
65(9):3837-45.
PMID: 15867382
To gain a better understanding of the mechanism of action of the metal cation-containing chemotherapeutic drug motexafin gadolinium (MGd), gene expression profiling analyses were conducted on plateau phase human lung...
6.
Evens A, Lecane P, Magda D, Prachand S, Singhal S, Nelson J, et al.
Blood
. 2004 Sep;
105(3):1265-73.
PMID: 15388578
Motexafin gadolinium (MGd), an expanded porphyrin, is a tumor-selective redox-mediator that reacts with many intracellular reducing metabolites. Because redox mechanisms mediate apoptosis in multiple myeloma, we hypothesized that disruption of...
7.
Magda D, Gerasimchuk N, Lecane P, Miller R, Biaglow J, Sessler J
Chem Commun (Camb)
. 2003 Jan;
(22):2730-1.
PMID: 12510321
Motexafin gadolinium (MGd) oxidizes ascorbate, in neutral buffer and in cell culture, forming reactive oxygen species and a coordination polymer with oxalate.