Richard A Miller
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Explore the profile of Richard A Miller including associated specialties, affiliations and a list of published articles.
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278
Citations
12481
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Recent Articles
1.
Elmansi A, Kassem A, Castilla R, Miller R
Geroscience
. 2024 Dec;
PMID: 39666139
Many aspects of inflammation increase with aging in mice and humans. Transcriptomic analysis revealed that many murine anti-aging interventions produce lower levels of pro-inflammatory proteins. Here, we explore the hypothesis...
2.
Lyu A, Fan Z, Clark M, Lea A, Luong D, Setayesh A, et al.
Nature
. 2024 Dec;
637(8048):1207-1217.
PMID: 39633050
Patients with advanced metastatic castration-resistant prostate cancer (mCRPC) are refractory to immune checkpoint inhibitors (ICIs), partly because there are immunosuppressive myeloid cells in tumours. However, the heterogeneity of myeloid cells...
3.
Yeh C, Chini L, Davidson J, Garcia G, Gallagher M, Freichels I, et al.
Nat Aging
. 2024 Nov;
4(12):1760-1771.
PMID: 39604703
Restricting the intake of protein or the branched-chain amino acid isoleucine promotes healthspan and extends lifespan in young or adult mice. However, their effects when initiated in aged animals are...
4.
Vikhorev A, Savelev I, Polesskaya O, Rempel M, Miller R, Vetcher A, et al.
Int J Mol Sci
. 2024 Oct;
25(20).
PMID: 39456831
Purine stretches, sequences of adenine (A) and guanine (G) in DNA, play critical roles in binding regulatory protein factors and influence gene expression by affecting DNA folding. This study investigates...
5.
Elmansi A, Miller R
Free Radic Biol Med
. 2024 Aug;
224:246-255.
PMID: 39153667
Oxidative metabolism declines with aging in humans leading to multiple metabolic ailments and subsequent inflammation. In mice, there is evidence of age-related suppression of fatty acid oxidation and oxidative phosphorylation...
6.
7.
Miller R, Harrison D, Cortopassi G, Dehghan I, Fernandez E, Garratt M, et al.
Geroscience
. 2024 Jul;
PMID: 39004654
No abstract available.
8.
Poudel S, Ruff R, Yildirim G, Miller R, Harrison D, Strong R, et al.
Arthritis Res Ther
. 2024 Jun;
26(1):118.
PMID: 38851726
Background: Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is a major contributing factor to OA, and as one ages, various...
9.
Jayarathne H, Sullivan R, Stilgenbauer L, Debarba L, Kuchumov A, Koshko L, et al.
Geroscience
. 2024 May;
46(5):4479-4493.
PMID: 38801647
The hypothalamus undergoes significant changes with aging and plays crucial roles in age-related metabolic alterations. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are anti-diabetic agents that promote glucose excretion, and metabolic homeostasis....
10.
Huang S, Cox R, Tuckowski A, Beydoun S, Bhat A, Howington M, et al.
Geroscience
. 2024 May;
46(5):4689-4706.
PMID: 38787463
Dietary restriction (DR) and hypoxia (low oxygen) extend lifespan in Caenorhabditis elegans through the induction of a convergent downstream longevity gene, fmo-2. Flavin-containing monooxygenases (FMOs) are highly conserved xenobiotic-metabolizing enzymes...