Darren Magda
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Explore the profile of Darren Magda including associated specialties, affiliations and a list of published articles.
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28
Citations
377
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Recent Articles
1.
Ho K, Tatum D, Watkinson L, Carmack T, Jia F, Mascioni A, et al.
J Nucl Med
. 2024 Aug;
65(9):1435-1442.
PMID: 39142831
Here we describe an anti-prostate-specific membrane antigen (PSMA) minibody (IAB2MA) conjugated to an octadentate, macrocyclic chelator based on four 1-hydroxypyridin-2-one coordinating units (Lumi804 [L804]) labeled with Zr (PET imaging) and...
2.
Abou D, Longtine M, Fears A, Benabdallah N, Unnerstall R, Johnston H, et al.
J Nucl Med
. 2023 May;
64(7):1062-1068.
PMID: 37142300
Th is a promising radioisotope for targeted α-particle therapy. It produces 5 α-particles through its decay, with the clinically approved Ra as its first daughter. There is an ample supply...
3.
Foster A, Nigam S, Tatum D, Raphael I, Xu J, Kumar R, et al.
EBioMedicine
. 2021 Sep;
71:103571.
PMID: 34530385
Background: Malignant gliomas are deadly tumours with few therapeutic options. Although immunotherapy may be a promising therapeutic strategy for treating gliomas, a significant barrier is the CD11b tumour-associated myeloid cells...
4.
Chen T, Hong R, Magda D, Bieniarz C, Morrison L, Miller L
Anal Chem
. 2017 Nov;
89(23):12713-12719.
PMID: 29115129
Multiplexed immunofluorescence imaging of formalin-fixed, paraffin-embedded tissues is a powerful tool for investigating proteomic profiles and diagnosing disease. However, conventional immunofluorescence with organic dyes is limited in the number of...
5.
Bhatt N, Pandya D, Xu J, Tatum D, Magda D, Wadas T
PLoS One
. 2017 Jun;
12(6):e0178767.
PMID: 28575044
The development of bifunctional chelators (BFCs) for zirconium-89 immuno-PET applications is an area of active research. Herein we report the synthesis and evaluation of octadentate hydroxyisophthalamide ligands (1 and 2)...
6.
Tinianow J, Pandya D, Pailloux S, Ogasawara A, Vanderbilt A, Gill H, et al.
Theranostics
. 2016 Mar;
6(4):511-21.
PMID: 26941844
A novel octadentate 3-hydroxypyridin-2-one (2,3-HOPO) based di-macrocyclic ligand was evaluated for chelation of (89)Zr; subsequently, it was used as a bi-functional chelator for preparation of (89)Zr-labeled antibodies. Quantitative chelation of...
7.
Zou X, Rajendran M, Magda D, Miller L
Bioconjug Chem
. 2015 Feb;
26(3):460-5.
PMID: 25675354
Strategies that leverage bio-orthogonal interactions between small molecule ligands and genetically encoded amino acid sequences can be used to attach high-performance fluorophores to proteins in living cells. However, a major...
8.
Pandya D, Pailloux S, Tatum D, Magda D, Wadas T
Chem Commun (Camb)
. 2015 Jan;
51(12):2301-3.
PMID: 25556851
The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate...
9.
Preihs C, Arambula J, Magda D, Jeong H, Yoo D, Cheon J, et al.
Inorg Chem
. 2013 Apr;
52(21):12184-92.
PMID: 23557113
Texaphyrins are pentaaza expanded porphyrins with the ability to form stable complexes with a variety of metal cations, particularly those of the lanthanide series. In biological milieus, texaphyrins act as...
10.
Mohandessi S, Rajendran M, Magda D, Miller L
Chemistry
. 2012 Jul;
18(35):10825-9.
PMID: 22807190
Release after transmission: Arginine-rich, cell-penetrating peptides (CPPs) mediate cytoplasmic delivery of trimethoprim (TMP)-terbium complex conjugates and selective, intracellular labeling of E. coli dihydrofolate reductase (eDHFR) fusion proteins. A disulfide bond...