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Jonathan L Sessler

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Articles 543
Citations 5501
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Recent Articles
1.
Yang Y, Zhang Q, Jin X, Chau C, Yang J, Henkelman G, et al.
Angew Chem Int Ed Engl . 2025 Mar; :e202501245. PMID: 40080464
Mounting concerns regarding per-/poly-fluoroalkyl substances (PFAS) on human health are focusing attention on trace level PFAS detection in aqueous environments. Here we report a readily prepared small molecule, 2,6-bis(3,5-diethyl-1H-pyrrol-2-yl)pyridine (receptor...
2.
He H, Lee J, Zong Z, Liu N, Noh Y, Lynch V, et al.
Nat Commun . 2025 Feb; 16(1):1534. PMID: 39934131
Nanographenes, finite models of graphene sheets, are endowed with intriguing optical, electronic, and spintronic features. So-called heteroatom-doping, where one or more carbon is replaced by non-carbon light atoms has been...
3.
Sharma A, Lee M, Shi H, Won M, Arambula J, Sessler J, et al.
Chem . 2025 Jan; 4(10):2370-2383. PMID: 39830500
Nearly without exception, all known cancer chemotherapeutics elicit a resistance response over time. The resulting resistance is correlated with poor clinical outcomes. Here, we report an approach to overcoming resistance...
4.
Zhang H, Xie W, Yao Y, Tang Z, Ni W, Wang B, et al.
ACS Appl Mater Interfaces . 2024 Dec; 17(2):3038-3051. PMID: 39739671
Microneedle patches for topical administration of photodynamic therapy (PDT) sensitizers are attractive owing to their safety, selectivity, and noninvasiveness. However, low-efficiency photosensitizer delivery coupled with the limitations of the hypoxic...
5.
Zhou H, Zhang Y, Zheng Z, Wan J, Zhang H, Lin K, et al.
Chem Sci . 2024 Dec; 16(2):910-919. PMID: 39660291
A covalently bridged macrocycle (5) comprising two anthracene strands connected at the lactam positions of a diketopyrrolopyrrole (DPP) chromophore has been constructed. The crystal structure reveals that the central DPP...
6.
Heo N, Oh J, Li A, Lee K, He Q, Sessler J, et al.
Chem Sci . 2024 Dec; 16(1):449. PMID: 39650223
[This corrects the article DOI: 10.1039/D4SC03760J.].
7.
Zhou H, Pang X, Xie X, Lee Phillips D, Gong H, Sessler J, et al.
J Am Chem Soc . 2024 Dec; 146(50):34842-34851. PMID: 39637361
Active compound protection can allow inherently unstable molecules to be stabilized and latent reactivity to be masked. Synthetic receptors are attractive in terms of providing such protection. Nevertheless, preserving the...
8.
Sun G, Zhang X, Zheng Z, Zhang Z, Dong M, Sessler J, et al.
J Am Chem Soc . 2024 Sep; 146(38):26233-26242. PMID: 39269922
The efficient synthesis of chiral macrocycles with highly enantioselective recognition remains a challenge. We have addressed this issue by synthesizing a pair of chiral macrocycles, namely, /-BINOL[2], achieving total isolated...
9.
Hu X, Gan H, Gui W, Yan K, Sessler J, Yi D, et al.
Proc Natl Acad Sci U S A . 2024 Sep; 121(37):e2408716121. PMID: 39226360
Bacterial evolution, particularly in hospital settings, is leading to an increase in multidrug resistance. Understanding the basis for this resistance is critical as it can drive discovery of new antibiotics...
10.
Han P, Duan Z, Shao M, Sessler J, Lei C
Angew Chem Int Ed Engl . 2024 Aug; 64(1):e202413962. PMID: 39183712
An expanded carbaporphyrinoid analogue, octaphyrin(2,1,1,1,2,1,1,1), containing two rigid diphenylacetylene moieties is reported. In contrast to traditional pyrrolic macrocycles where flexible conformers coexist in dynamic equilibrium, this macrocycle exists as two...