Philip J Kingsley
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Explore the profile of Philip J Kingsley including associated specialties, affiliations and a list of published articles.
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64
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1887
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Recent Articles
1.
Semler E, Michell D, Kingsley P, Massick C, Ramirez M, Castleberry M, et al.
bioRxiv
. 2025 Jan;
PMID: 39763941
Epitranscriptomic modifications on RNA play critical roles in stability, processing, and function, partly by influencing interactions with RNA-binding proteins and receptors. The role of post-transcriptional RNA modifications on cell-free non-coding...
2.
Aleem A, Mitchener M, Kingsley P, Rouzer C, Marnett L
J Lipid Res
. 2024 Aug;
65(9):100615.
PMID: 39098584
Cyclooxygenase-2 converts arachidonic acid to prostaglandins (PGs) and the endocannabinoid, 2-arachidonoylglycerol (2-AG), to PG glyceryl esters (PG-Gs). The physiological function of PG biosynthesis has been extensively studied, but the importance...
3.
Uddin J, Lo J, Gupta M, Werfel T, Asaduzzaman A, Oltman C, et al.
bioRxiv
. 2024 Jun;
PMID: 38915607
We report the development of a nanotechnology to co-deliver chemocoxib A with a reactive oxygen species (ROS)-activatable and COX-2 targeted pro-fluorescent probe, fluorocoxib Q (FQ) enabling real time visualization of...
4.
Stone A, Pham A, Osmundson S, Pedowitz A, Kingsley P, Marnett L, et al.
J Pain
. 2024 Apr;
25(9):104548.
PMID: 38663651
Both endocannabinoid (EC) and endogenous opioid systems are involved in nociceptive processing and may work together synergistically based on preclinical models. This study evaluated the interactive effects of preoperative beta-endorphin...
5.
Fu Y, Christov P, Kingsley P, Richie-Jannetta R, Marnett L, Stone M
Chem Res Toxicol
. 2023 Nov;
36(12):1947-1960.
PMID: 37989274
The genotoxic 3-(2-deoxy-β-D-erythro-pentofuranosyl)pyrimido[1,2-α]purin-10(3H)-one (MdG) DNA lesion arises from endogenous exposures to base propenals generated by oxidative damage and from exposures to malondialdehyde (MDA), produced by lipid peroxidation. Once formed, MdG...
6.
Richie-Jannetta R, Pallan P, Kingsley P, Kamdar N, Egli M, Marnett L
J Biol Chem
. 2023 Jul;
299(8):105067.
PMID: 37468099
The DNA adduct 6-oxo-MdG, (3-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-oxo-pyrimido(1,2alpha)purin-10(3H)-one) is formed in the genome via oxidation of the peroxidation-derived adduct MdG. However, the effect of 6-oxo-MdG adducts on subsequent DNA replication is unclear. Here...
7.
Morrison V, Houpert M, Trapani J, Brockman A, Kingsley P, Katdare K, et al.
bioRxiv
. 2023 Mar;
PMID: 36945622
Microglia are the primary phagocytes in the central nervous system and are responsible for clearing dead cells generated during development or disease. The phagocytic process shapes the phenotype of the...
8.
Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages
Aleem A, Kang W, Lin S, Milad M, Kingsley P, Crews B, et al.
ACS Chem Biol
. 2023 Jan;
18(2):404-418.
PMID: 36638351
Necrostatin-1 blocks ferroptosis via an unknown mechanism and necroptosis through inhibition of receptor-interacting protein kinase-1 (RIP1). We report that necrostatin-1 suppresses cyclooxygenase-2-dependent prostaglandin biosynthesis in lipopolysaccharide-treated RAW264.7 macrophages (IC ∼...
9.
Kondev V, Morgan A, Najeed M, Winters N, Kingsley P, Marnett L, et al.
Biol Psychiatry
. 2022 Aug;
92(9):739-749.
PMID: 35961791
Background: Stress-related disorders are among the most prevalent psychiatric disorders, characterized by excess fear and enhanced avoidance of trauma triggers. Elucidating the mechanisms regulating temporally distinct aspects of innate and...
10.
Uddin M, Lo J, Oltman C, Crews B, Huda T, Liu J, et al.
ACS Chem Biol
. 2022 Jul;
17(7):1714-1722.
PMID: 35786843
Cyclooxygenase-2 (COX-2) expression is up-regulated in inflammatory tissues and many premalignant and malignant tumors. Assessment of COX-2 protein in vivo, therefore, promises to be a powerful strategy to distinguish pathologic...