Philip Bentley
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Explore the profile of Philip Bentley including associated specialties, affiliations and a list of published articles.
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10
Citations
258
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Recent Articles
1.
Lee E, Valencia T, Allerson C, Schairer A, Flaten A, Yheskel M, et al.
Nat Commun
. 2019 Sep;
10(1):4148.
PMID: 31515477
Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in either PKD1 or PKD2 genes, is one of the most common human monogenetic disorders and the leading genetic cause of...
2.
Moggs J, MacLachlan T, Martus H, Bentley P
Trends Cancer
. 2017 Jul;
2(8):398-408.
PMID: 28741493
Assessing the carcinogenic potential of innovative drugs spanning diverse therapeutic modalities and target biology represents a major challenge during drug development. Novel modalities, such as cell and gene therapies that...
3.
Yin Z, Chowdhury S, McKay C, Baniel C, Wright W, Bentley P, et al.
ACS Chem Biol
. 2015 Aug;
10(10):2364-72.
PMID: 26262839
Development of an effective vaccine targeting tumor associated carbohydrate antigens (TACAs) is an appealing approach toward tumor immunotherapy. While much emphasis has been typically placed on generating high antibody titers...
4.
Qin Q, Yin Z, Bentley P, Huang X
Medchemcomm
. 2014 Nov;
5(8):1126-1129.
PMID: 25396038
Tumor associated carbohydrate antigens (TACAs) are overexpressed on tumor cells, which renders them attractive targets for anti-cancer vaccines. To overcome the poor immunogenicity of TACAs, we designed a polymer platform...
5.
Yin Z, Comellas-Aragones M, Chowdhury S, Bentley P, Kaczanowska K, BenMohamed L, et al.
ACS Chem Biol
. 2013 Mar;
8(6):1253-62.
PMID: 23505965
The development of an effective immunotherapy is an attractive strategy toward cancer treatment. Tumor associated carbohydrate antigens (TACAs) are overexpressed on a variety of cancer cell surfaces, which present tempting...
6.
Yin Z, Nguyen H, Chowdhury S, Bentley P, Bruckman M, Miermont A, et al.
Bioconjug Chem
. 2012 Jul;
23(8):1694-703.
PMID: 22812480
Tumor-associated carbohydrate antigens (TACAs) are being actively studied as targets for antitumor vaccine development. One serious challenge was the low immunogenecity of these antigens. Herein, we report the results of...
7.
Mondal M, Gabriels J, McGinnis C, Magnifico M, Marsilje T, Urban L, et al.
Toxicol Sci
. 2010 Jul;
118(1):71-85.
PMID: 20631060
This article describes the first step toward full (that includes conditions for both absence and presence of metabolic activation) validation and drug discovery application of a 96-well, automated, high-content micronucleus...
8.
Preparation of diphenyl phosphide and substituted phosphines using alkali metal in silica gel (M-SG)
Nandi P, Dye J, Bentley P, Jackson J
Org Lett
. 2009 Mar;
11(8):1689-92.
PMID: 19296649
Alkali metals absorbed in silica gel (the M-SG reagents) efficiently cleave C-P bonds in triaryl- and diarylphosphines. The resulting alkali metal phosphides can serve as useful building blocks for a...
9.
Vickers A, Rose K, Fisher R, Saulnier M, Sahota P, Bentley P
Toxicol Pathol
. 2004 Dec;
32(5):577-90.
PMID: 15603542
Kidney slices represent an in vitro model that has the cellular complexity of in vivo tissue to provide insights into mechanisms of organ injury, as shown in this study with...
10.
Vickers A, Saulnier M, Cruz E, Merema M, Rose K, Bentley P, et al.
Toxicol Sci
. 2004 Oct;
82(2):534-44.
PMID: 15456927
Liver slice viability is extended to 96 h for rat, expanding the use of this in vitro model for studying mechanisms of injury and repair, including pathways of fibrosis. The...