Jeffrey C Gildersleeve
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Explore the profile of Jeffrey C Gildersleeve including associated specialties, affiliations and a list of published articles.
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82
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1804
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Recent Articles
1.
Chen S, Putnik R, Li X, Diwaker A, Vasconcelos M, Liu S, et al.
Nat Commun
. 2025 Feb;
16(1):1864.
PMID: 39984444
Peptidoglycan recognition proteins (PGLYRPs) are implicated in the control of the intestinal microbiota; however, molecular requirements for peptidoglycan (PGN) binding and receptor signaling mechanisms remain poorly understood. Here we show...
2.
Orfanoudaki M, Krumpe L, Shenoy S, Wilson J, Guszczynski T, Henrich C, et al.
J Biol Chem
. 2025 Feb;
301(3):108319.
PMID: 39956341
An anti-HIV screen of natural product extracts resulted in the discovery of a new antiviral protein through bioassay-guided fractionation of an aqueous extract of the ascidian Didemnum molle. The protein...
3.
Temme J, Tan Z, Li M, Yang M, Wlodawer A, Huang X, et al.
Cell Chem Biol
. 2024 Dec;
31(12):2096-2111.e7.
PMID: 39637855
Polysaccharide intercellular adhesin (PIA), an exopolysaccharide composed of poly-N-acetyl glucosamine (PNAG), is an essential component in many pathogenic biofilms. Partial deacetylation of PNAG is required for biofilm formation, but limited...
4.
Chen S, Putnik R, Li X, Diwaker A, Vasconcelos M, Liu S, et al.
Res Sq
. 2024 Nov;
PMID: 39483916
Peptidoglycan recognition proteins (PGRPs or PGLYRPs) are implicated in the control of the intestinal microbiota; however, molecular requirements for peptidoglycan (PGN) binding and receptor signaling mechanisms remain poorly understood. We...
5.
Le Coz C, Trofa M, Butler D, Yoon S, Tian T, Reid W, et al.
J Allergy Clin Immunol
. 2024 May;
154(3):778-791.e9.
PMID: 38692308
Background: Autoimmune cytopenias (AICs) regularly occur in profoundly IgG-deficient patients with common variable immunodeficiency (CVID). The isotypes, antigenic targets, and origin(s) of their disease-causing autoantibodies are unclear. Objective: We sought...
6.
Tan Z, Yang W, OBrien N, Pan X, Ramadan S, Marsh T, et al.
Nat Commun
. 2024 Apr;
15(1):3420.
PMID: 38658531
Poly-β-(1-6)-N-acetylglucosamine (PNAG) is an important vaccine target, expressed on many pathogens. A critical hurdle in developing PNAG based vaccine is that the impacts of the number and the position of...
7.
Marglous S, Brown C, Padler-Karavani V, Cummings R, Gildersleeve J
Chem Soc Rev
. 2024 Feb;
53(5):2603-2642.
PMID: 38305761
Humans and other animals produce a diverse collection of antibodies, many of which bind to carbohydrate chains, referred to as glycans. These anti-glycan antibodies are a critical part of our...
8.
Rashidijahanabad Z, Ramadan S, OBrien N, Nakisa A, Lang S, Crawford H, et al.
Angew Chem Int Ed Engl
. 2023 Oct;
62(47):e202309744.
PMID: 37781858
Sialyl Lewis (sLe ), also known as cancer antigen 19-9 (CA19-9), is a tumor-associated carbohydrate antigen. The overexpression of sLe on the surface of a variety of cancer cells makes...
9.
Gillmann K, Temme J, Marglous S, Brown C, Gildersleeve J
Curr Opin Chem Biol
. 2023 Mar;
74:102281.
PMID: 36905763
Anti-glycan monoclonal antibodies have important applications in human health and basic research. Therapeutic antibodies that recognize cancer- or pathogen-associated glycans have been investigated in numerous clinical trials, resulting in two...
10.
Temme J, Crainic J, Walker L, Yang W, Tan Z, Huang X, et al.
J Biol Chem
. 2022 Sep;
298(10):102468.
PMID: 36087840
The immune system produces a diverse collection of antiglycan antibodies that are critical for host defense. At present, however, we know very little about the binding properties, origins, and sequences...