Philip Anton van der Merwe
Overview
Explore the profile of Philip Anton van der Merwe including associated specialties, affiliations and a list of published articles.
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6
Citations
178
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Recent Articles
1.
Barton M, Paterson R, Denham E, Goyette J, van der Merwe P
Commun Biol
. 2024 Sep;
7(1):1138.
PMID: 39271744
Leukocytes interact with other cells using cell surface receptors. The largest group of such receptors are non-catalytic tyrosine phosphorylated receptors (NTRs), also called immunoreceptors. NTR signalling requires phosphorylation of cytoplasmic...
2.
Limozin L, Bridge M, Bongrand P, Dushek O, van der Merwe P, Robert P
Proc Natl Acad Sci U S A
. 2019 Jul;
116(34):16943-16948.
PMID: 31315981
The T cell receptor (TCR)-peptide-MHC (pMHC) interaction is the only antigen-specific interaction during T lymphocyte activation. Recent work suggests that formation of catch bonds is characteristic of activating TCR-pMHC interactions....
3.
Lever M, Lim H, Kruger P, Nguyen J, Trendel N, Abu-Shah E, et al.
Proc Natl Acad Sci U S A
. 2016 Oct;
113(43):E6630-E6638.
PMID: 27702900
T cells must respond differently to antigens of varying affinity presented at different doses. Previous attempts to map peptide MHC (pMHC) affinity onto T-cell responses have produced inconsistent patterns of...
4.
Brodovitch A, Shenderov E, Cerundolo V, Bongrand P, Pierres A, van der Merwe P
Eur J Immunol
. 2015 Mar;
45(6):1635-42.
PMID: 25782169
T lymphocytes need to detect rare cognate foreign peptides among numerous foreign and self-peptides. This discrimination seems to be based on the kinetics of TCRs binding to their peptide-MHC (pMHC)...
5.
Kohler K, Xiong S, Brzostek J, Mehrabi M, Eissmann P, Harrison A, et al.
PLoS One
. 2010 Dec;
5(11):e15374.
PMID: 21179506
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling. Here, we set out to test...
6.
Aricescu A, Hon W, Siebold C, Lu W, van der Merwe P, Jones E
EMBO J
. 2006 Feb;
25(4):701-12.
PMID: 16456543
Type IIB receptor protein tyrosine phosphatases (RPTPs) are bi-functional cell surface molecules. Their ectodomains mediate stable, homophilic, cell-adhesive interactions, whereas the intracellular catalytic regions can modulate the phosphorylation state of...