Shaun-Paul Cordoba
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Explore the profile of Shaun-Paul Cordoba including associated specialties, affiliations and a list of published articles.
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11
Citations
397
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Recent Articles
1.
Oszmiana A, Williamson D, Cordoba S, Morgan D, Kennedy P, Stacey K, et al.
Cell Rep
. 2016 May;
15(9):1957-72.
PMID: 27210755
Super-resolution microscopy has revealed that immune cell receptors are organized in nanoscale clusters at cell surfaces and immune synapses. However, mechanisms and functions for this nanoscale organization remain unclear. Here,...
2.
Lim H, Cordoba S, Dushek O, Goyette J, Taylor A, Rudd C, et al.
J Immunol
. 2015 Oct;
195(11):5432-9.
PMID: 26500347
Optimal T cell activation typically requires engagement of both the TCR and costimulatory receptors, such as CD28. Engagement of CD28 leads to tyrosine phosphorylation of its cytoplasmic region and recruitment...
3.
Paster W, Bruger A, Katsch K, Gregoire C, Roncagalli R, Fu G, et al.
EMBO J
. 2014 Dec;
34(3):393-409.
PMID: 25535246
THEMIS is critical for conventional T-cell development, but its precise molecular function remains elusive. Here, we show that THEMIS constitutively associates with the phosphatases SHP1 and SHP2. This complex requires...
4.
Pageon S, Cordoba S, Owen D, Rothery S, Oszmiana A, Davis D
Sci Signal
. 2013 Jul;
6(285):ra62.
PMID: 23882121
Natural killer (NK) cell responses are regulated by a dynamic equilibrium between activating and inhibitory receptor signals at the immune synapse (or interface) with target cells. Although the organization of...
5.
Cordoba S, Choudhuri K, Zhang H, Bridge M, Basat A, Dustin M, et al.
Blood
. 2013 Apr;
121(21):4295-302.
PMID: 23580664
T-cell receptor (TCR) triggering results in a cascade of intracellular tyrosine phosphorylation events that ultimately leads to T-cell activation. It is dependent on changes in the relative activities of membrane-associated...
6.
Mukhopadhyay H, Cordoba S, Maini P, Anton van der Merwe P, Dushek O
PLoS Comput Biol
. 2013 Apr;
9(3):e1003004.
PMID: 23555234
Receptor phosphorylation is thought to be tightly regulated because phosphorylated receptors initiate signaling cascades leading to cellular activation. The T cell antigen receptor (TCR) on the surface of T cells...
7.
Anton van der Merwe P, Zhang H, Cordoba S
Front Immunol
. 2012 May;
3:29.
PMID: 22566913
Based on studies in model systems it has been proposed that the cytoplasmic domains of T cell receptor signaling subunits that have polybasic motifs associate with the plasma membrane, and...
8.
Zhang H, Cordoba S, Dushek O, Anton van der Merwe P
Proc Natl Acad Sci U S A
. 2011 Nov;
108(48):19323-8.
PMID: 22084078
The T-cell receptor (TCR) consists of a TCRαβ heterodimer, a TCRζ homodimer, and CD3γε and CD3δε heterodimers. The precise mechanism of T-cell triggering following TCR ligand engagement remains elusive. Previous...
9.
Dushek O, Aleksic M, Wheeler R, Zhang H, Cordoba S, Peng Y, et al.
Sci Signal
. 2011 Jun;
4(176):ra39.
PMID: 21653229
T cell activation, a critical event in adaptive immune responses, depends on productive interactions between T cell receptors (TCRs) and antigens presented as peptide-bound major histocompatibility complexes (pMHCs). Activated T...
10.
Anton van der Merwe P, Cordoba S
Immunity
. 2011 Jan;
34(1):1-3.
PMID: 21272780
In this issue of Immunity, Jiang et al. (2011) provide evidence that the CD8 coreceptor is recruited to the T cell receptor (TCR) complex after initial TCR triggering where it...