Petra Verdino
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Explore the profile of Petra Verdino including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
862
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Recent Articles
1.
Tham L, Heerspink H, Wang X, Verdino P, Saifan C, Benson E, et al.
Nephrol Dial Transplant
. 2024 May;
40(1):109-122.
PMID: 38782726
Background: Volenrelaxin is a half-life-extended recombinant human relaxin protein developed for improving kidney perfusion and cardiorenal function. This study assessed the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of volenrelaxin...
2.
Verdino P, Lee S, Cooper F, Cottle S, Grealish P, Hu C, et al.
Br J Pharmacol
. 2023 Feb;
180(15):1965-1980.
PMID: 36780899
Background And Purpose: Chronic heart failure, a progressive disease with limited treatment options currently available, especially in heart failure with preserved ejection fraction (HFpEF), represents an unmet medical need as...
3.
Lin J, Lee S, Russell A, Huang R, Batt M, Chang S, et al.
PLoS One
. 2021 Jul;
16(7):e0254944.
PMID: 34297759
Development of biotherapeutics is hampered by the inherent risk of immunogenicity, which requires extensive clinical assessment and possible re-engineering efforts for mitigation. The focus in the pre-clinical phase is to...
4.
Bowers P, Verdino P, Wang Z, da Silva Correia J, Chhoa M, Macondray G, et al.
J Biol Chem
. 2014 Oct;
289(48):33557-67.
PMID: 25320089
During somatic hypermutation (SHM), deamination of cytidine by activation-induced cytidine deaminase and subsequent DNA repair generates mutations within immunoglobulin V-regions. Nucleotide insertions and deletions (indels) have recently been shown to...
5.
Jimenez-Dalmaroni M, Radcliffe C, Harvey D, Wormald M, Verdino P, Ainge G, et al.
Innate Immun
. 2014 Mar;
21(2):175-93.
PMID: 24591200
TLRs are key innate immune receptors that recognize conserved features of biological molecules that are found in microbes. In particular, TLR2 has been reported to be activated by different kinds...
6.
Bowers P, Horlick R, Kehry M, Neben T, Tomlinson G, Altobell L, et al.
Methods
. 2013 Jun;
65(1):44-56.
PMID: 23792919
Recent advances are described for the isolation and affinity maturation of antibodies that couple in vitro somatic hypermutation (SHM) with mammalian cell display, replicating key aspects of the adaptive immune...
7.
Horlick R, Macomber J, Bowers P, Neben T, Tomlinson G, Krapf I, et al.
J Biol Chem
. 2013 May;
288(27):19861-9.
PMID: 23689374
A mammalian expression system has been developed that permits simultaneous cell surface display and secretion of the same protein through alternate splicing of pre-mRNA. This enables a flexible system for...
8.
Bowers P, Neben T, Tomlinson G, Dalton J, Altobell L, Zhang X, et al.
J Biol Chem
. 2013 Jan;
288(11):7688-7696.
PMID: 23355464
A method for simultaneous humanization and affinity maturation of monoclonal antibodies has been developed using heavy chain complementarity-determining region (CDR) 3 grafting combined with somatic hypermutation in vitro. To minimize...
9.
Witherden D, Watanabe M, Garijo O, Rieder S, Sarkisyan G, Cronin S, et al.
Immunity
. 2012 Aug;
37(2):314-25.
PMID: 22902232
γδ T cells respond rapidly to keratinocyte damage, providing essential contributions to the skin wound healing process. The molecular interactions regulating their response are unknown. Here, we identify a role...
10.
Verdino P, Witherden D, Podshivalova K, Rieder S, Havran W, Wilson I
PLoS One
. 2011 Jun;
6(5):e19828.
PMID: 21629689
Hamsters are widely used to generate monoclonal antibodies against mouse, rat, and human antigens, but sequence and structural information for hamster immunoglobulins is sparse. To our knowledge, only three hamster...